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Etrasimod
go.drugbank.com/drugs/DB14766ApprovedInvestigational[A261826] In fact, it has been observed that antigen-activated T cells within peripheral lymphoid organs can transiently downregulate S1P receptor levels to facilitate immune cells trafficking into the … Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P<sub>1,4,5</sub> with no detectable activity on S1P<sub>2</sub> and S1P<sub>3</sub
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingTeriparatide
go.drugbank.com/drugs/DB06285ApprovedInvestigational[A251395] Teriparatide is used in the treatment of osteoporosis in men and women.[L42590, L42595] … Teriparatide is a recombinant parathyroid hormone (PTH) analog and a potent osteoanabolic agent.[A251395] It is made up of the first amino(N)-terminal 34 amino acids of the human PTH.
Synonyms: PTH 1-34, PTH (1-34)Products: TEOTIDE®, TERROSA®Pemigatinib
go.drugbank.com/drugs/DB15102ApprovedInvestigationalgrowth factor receptor 2 (FGFR2) gene fusion or other rearrangements as detected by an FDA-approved test. … [A198984] Deregulated FGFR signalling pathway can lead the development of oncogenes and tumour-promoting physiological processes, such as cancer cell proliferation, enhanced angiogenesis, and evasion of
Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesSertaconazole
go.drugbank.com/drugs/DB01153ApprovedSertaconazole nitrate is an antifungal medication of the imidazole class. It is available in topical formulations for the treatment of skin infections such as athlete's foot.
Categories: Heterocyclic Compounds, 1-RingProducts: Konzert Cream 2%w/w, ZALAIN® 2% CREMATafenoquine
go.drugbank.com/drugs/DB06608ApprovedInvestigationalTafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy group. … [A35671, A35690] It was discovered by the scientists at the Walter Reed Army Institute of Research in 1978 as a substitute for primaquine that would be more effective against relapsing vivax malaria.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsOnasemnogene abeparvovec
go.drugbank.com/drugs/DB15528ApprovedInvestigationalOnasemnogene abeparvovec is an adeno-associated virus vector-based gene therapy that has been approved by the FDA in May 2019 for the treatment of infant patients (less than 2 years of age) with spinal … [L9194] Onasemnogene abeparvovec for therapeutic use and marketing is currently being assessed by the EU and an intrathecal formulation of the drug is currently undergoing clinical development in the USA
Dapiprazole
go.drugbank.com/drugs/DB00298ApprovedDapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. It is found in ophthalmic solutions used to reverse mydriasis after an eye examination.
Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-1 Receptor AntagonistsSynonyms: 5,6,7,8-Tetrahydro-3-(2-(4-(o-tolyl)-1-piperazinyl)ethyl)-s-triazolo(4,3-a)pyridineCetuximab
go.drugbank.com/drugs/DB00002ApprovedInvestigational[A227963] EGFR is often mutated in certain types of cancer and serves as a driver of tumorigenesis. … Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor
Products: ERBITUX ® 5 MG/ML, ERBITUX® 5 MG/MLFatigue
go.drugbank.com/conditions/DBCOND0012333Dexbrompheniramine
go.drugbank.com/drugs/DB00405ApprovedDexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria.
Mixtures: M-end Max D, G-Con-XCategories: Heterocyclic Compounds, 1-Ring