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Glymidine
go.drugbank.com/drugs/DB01382ApprovedThe mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral … Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin.
Categories: combinations of sulfonamidesLevoleucovorin
go.drugbank.com/drugs/DB11596ApprovedInvestigationalThey are indicated for use as rescue therapy following use of high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid … This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects of methotrexate therapy.
Categories: Compounds used in a research, industrial, or household settingAntihemophilic factor (recombinant), PEGylated
go.drugbank.com/drugs/DB09329ApprovedInvestigationalPEGylation is the covalent attachment of a polyethylene glycol polymer, called PEG, to a drug or protein. … It has been created to increase the half-life of factor VIII, which decreases dose frequency and decreases the occurrence of bleeding events [A32067], [A32069], [FDA label].
Categories: Compounds used in a research, industrial, or household settingSulfoxone
go.drugbank.com/drugs/DB01145ApprovedIt has been used with limited success in the treatment of dermatitis herpetiformis.
Categories: Drugs for Treatment of LepraDaclatasvir
go.drugbank.com/drugs/DB09102ApprovedInvestigationalWithdrawnThe therapy is intended to cure or achieve a sustained virologic response (SVR12), after 12 weeks of daily therapy. … According to 2017 American Association for the Study of Liver Diseases (AASLD), 60mg of daclatasvir is recommended with 400mg [DB08934] for genotype 1a/b patients with or without cirrhosis as second-line
Categories: Antivirals for treatment of HCV infectionsProducts: DASVIR 30 (DACLATASVIR TABLETS 30 MG), DASVIR 60 (DACLATASVIR TABLETS 60 MG)Droloxifene
go.drugbank.com/drugs/DB15641Experimentalgive it theoretical advantages over tamoxifen in the treatment of human breast cancer. … Droloxifene may have an effect on bone and breast tissue because it induces apoptosis.
Categories: Compounds used in a research, industrial, or household settingCalaspargase pegol
go.drugbank.com/drugs/DB14730ApprovedInvestigationalCalaspargase pegol, also known as _asparlas_, is an asparagine specific enzyme which is indicated as a part of a multi-agent chemotherapy regimen for the treatment of ALL [L4890]. … This forms the basis of asparaginase treatment in ALL [A40270], [A40273], [F2432].
Categories: Compounds used in a research, industrial, or household settingTibolone
go.drugbank.com/drugs/DB09070ApprovedInvestigationalTibolone (Livial, Org OD 14), produced by Organon (West Orange, NJ), is a synthetic steroid that possesses estrogenic, androgenic and progestogenic properties. … It has been used in Europe for almost 2 decades, primarily for the prevention of postmenopausal osteoporosis and the treatment of post-menopausal symptoms [L1720].
Categories: Sex Hormones and Modulators of the Genital SystemProducts: LIVIAL TABLET 2.5 mg, TINOX 2.5 MG TABLETAAcetyl sulfisoxazole
go.drugbank.com/drugs/DB14033ApprovedVet approvedSulfisoxazole acetyl is an ester of _sulfisoxazole_, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. … This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, resulting in cell growth arrest and cell death [L2788].
Categories: combinations of sulfonamidesDiethylstilbestrol
go.drugbank.com/drugs/DB00255ApprovedWithdrawn(Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.[L43942] … According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen.
Categories: Sex Hormones and Modulators of the Genital SystemProducts: Stilbestrol Tablets 1.0 mg, Stilbestrol Tablets 0.1 mg