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Displaying results 1381 - 1390 of 10000 in total
  1. Drug

    Raltegravir

    go.drugbank.com/drugs/DB06817
    ApprovedInvestigational

    Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. … Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval.

    Categories: lamivudine and raltegravirProducts: ISENTRESS® TABLETAS MASTICABLES 100MG
  2. Drug

    Peppermint

    go.drugbank.com/drugs/DB10984
    Approved

    Peppermint allergenic extract is used in allergenic testing.

    Mixtures: Bio-strath No. 8 GouttesCategories: Herbs and Natural Products, Non-Standardized Food Allergenic Extract
  3. Target

    NACHT, LRR and PYD domains-containing protein 3

    go.drugbank.com/bio_entities/BE0010347
    TargetHumans

    Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD … Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis

    Polypeptides: NACHT, LRR and PYD domains-containing protein 3
  4. Target

    Zinc finger and BTB domain-containing protein 7A

    go.drugbank.com/bio_entities/BE0012406
    TargetHumans

    Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription … That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493).

    Polypeptides: Zinc finger and BTB domain-containing protein 7ASynonyms: POZ and Krueppel erythroid myeloid ontogenic factor
  5. Drug

    Benzylpenicillin

    go.drugbank.com/drugs/DB01053
    ApprovedInvestigationalVet approved

    Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by *Neisseria meningitidis* and *Pasteurella*. … Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria.

    Products: Crystapen 10m I.U., Penicillin G Na for Inj USP 5000000u/vial
  6. Drug

    Azatadine

    go.drugbank.com/drugs/DB00719
    ApprovedWithdrawn

    The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury … Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells.

    Mixtures: CO-TYLENOLProducts: Optimine Tab 1mg
  7. Drug

    Belimumab

    go.drugbank.com/drugs/DB08879
    ApprovedInvestigational

    [A251495, L42705] By binding to BLyS and blocking its interaction with B cell receptors, belimumab inhibits the survival of B cells. … [A251520] It is currently used to treat SLE and lupus nephritis.[L42630]

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: Benlysta Powder for Solution for Infusion 120mg
  8. Drug

    Biotin

    go.drugbank.com/drugs/DB00121
    ApprovedInvestigationalNutraceutical

    A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.

    Mixtures: Iron 25mg With Vit B-cmplx, Vit C, Cu & Mo, B Complex 25mg Vitamin SupplementCategories: Enzymes and Coenzymes, Diet, Food, and Nutrition
  9. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 4

    go.drugbank.com/bio_entities/BE0004687
    EnzymeTargetHumans

    Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). … May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 4
  10. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 13

    go.drugbank.com/bio_entities/BE0009336
    EnzymeTargetHumans

    Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13