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NGX267 Action Pathway
smpdb.ca/view/SMP0126364Drug actionIt is developed for the treatment of Alzheimer’s disease and has shown the potential to both reduce symptoms and slow disease progression. … The M1 receptor plays an important role in memory and cognitive processing.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Trihexyphenidyl Action Pathway
smpdb.ca/view/SMP0126395Drug actionStructures innervated by the parasympathetic system, such as the salivary glands, eyes, and smooth muscles (directly and indirectly), are affected, even at smaller doses. … Trihexyphenidyl is an antispasmodic drug used as an adjunct drug in the management of parkinsonism and as a treatment for extrapyramidal symptoms caused by drugs affecting the central nervous system (CNS
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Pyridostigmine Action Pathway
smpdb.ca/view/SMP0126623Drug actionIt is usually administered intravenously and is very similar to neostigmine but with a less adverse effect profile and longer duration of action. … It specifically targets and inhibits acetylcholinesterase and cholinesterase, this increases extracellular levels of acetylcholine.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FIsoflurophate Action Pathway (new)
smpdb.ca/view/SMP0126686Drug actionIsoflurophate is a cholinesterase inhibitor used to treat glaucoma, as it acts as a powerful miotic agent constricting the pupil and causing the aqueous fluid to flow out and relieve pressure. … It acts by irreversibly binding to acetylcholinesterase and cholinesterase, inhibiting them from breaking down acetylcholine.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Demecarium Action Pathway (new)
smpdb.ca/view/SMP0126687Drug actionprotein receptors and initiating a downstream cascade of effects. … It is a long-acting cholinesterase and very potent, due to this should only be used in patients with open-angle glaucoma.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Rivastigmine Action Pathway (new)
smpdb.ca/view/SMP0126688Drug actionThe drug reversible binds to and inhibits acetylcholinesterase and cholinesterase which stops the breakdown of acetylcholine which increases the concentration in the synaptic cleft. … It is metabolized by the enzymes it inhibits and forms the metabolite NAP226-90.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Ambenonium Action Pathway (new)
smpdb.ca/view/SMP0126691Drug actionAcetylcholine stimulates the nicotinic acetylcholine receptors and causes a cascade resulting in muscle contraction. … Ambenonium allows acetylcholine to be present in the neuromuscular junction for longer and increases the chances of signal transmission.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FMalathion Action Pathway
smpdb.ca/view/SMP0126697Drug actionIt is administered through a topical application which is readily absorbed by the insects, and only 8% by human skin. … It is metabolized into metabolites known as malathion dicarboxylic acid, malathion monocarboxylic acid and malaoxon.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FEchothiophate Action Pathway
smpdb.ca/view/SMP0126704Drug actionSide effects such as change in vision both near or far, eye pain and blurred vision can occur. … Doing so causes miosis (constriction of the pupil) causing an outflow of aqueous humor and reducing intraocular pressure.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Phenserine Action Pathway
smpdb.ca/view/SMP0126724Drug actionIt acts as a highly selective reversible acetylcholinesterase inhibitor, which is known to increase acetylcholine levels in the synaptic cleft and enhance the interaction between the neurotransmitter and … This mechanism of action is known to improve memory and cognition in alzheimer's subjects.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1