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Tetrabenazine
go.drugbank.com/drugs/DB04844ApprovedA drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. … It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesProducts: Dystardis 25 mg Tabletten, Tetmodis 25 mg TablettenOsimertinib
go.drugbank.com/drugs/DB09330ApprovedInvestigationalApproximately 10% of patients with NSCLC have a rapid and clinically effective response to EGFR-TKIs due to the presence of specific activating EGFR mutations within the tumour cells. … [A7928] Development of third-generation EGFR-TKIs, such as osimertinib, has been in response to altered tumour resistance patterns following treatment and toxic side effects that impact patient quality
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InducersSynonyms: N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamideEtonogestrel
go.drugbank.com/drugs/DB00294ApprovedInvestigational[A37184] The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.[L5692]
Mixtures: Perlinring 0,120 mg/0,015 mg pro 24 Stunden - Vaginalring, NuvaRing 0,120 mg/0,015 mg pro 24 Stunden - VaginalringCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesRotigotine
go.drugbank.com/drugs/DB05271ApprovedInvestigationalRotigotine has been authorized as a treatment for RLS since August 2008. … Like other dopamine agonists, rotigotine has been shown to possess antidepressant effects and may be useful in the treatment of depression as well.
Categories: Serotonin 5-HT1 Receptor Agonists, Cytochrome P-450 SubstratesProducts: NEUPRO® 6 MG/24 H, NEUPRO® 4 MG /24 HTrametinib
go.drugbank.com/drugs/DB08911ApprovedInvestigational[A258298] It was later approved by Health Canada on July 18, 2013 [L45588] and by the European Commission on June 30, 2014. … [L45583] Trametinib is currently approved to treat a variety of cancers with BRAF mutations, such as non-small cell lung cancer and thyroid cancer, as monotherapy or in combination with [dabrafenib], a
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: MEKINIST 0.5 MG FILM KAPLI TABLET ,TABLET, 30 ADET, MEKINIST 2 MG FILM KAPLI TABLET ,TABLET, 30 ADETTafluprost
go.drugbank.com/drugs/DB08819ApprovedTafluprost was approved for use in the U.S. on February 10, 2012. … A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
Mixtures: TAPCOM-S ophthalmic solution 15 micrograms/ml + 5 mg/ml, solution in single-dose container, Taptiqom 15 Mikrogramm/ml + 5 mg/ml Augentropfen, Lösung im EinzeldosisbehältnisProducts: SAFLUTAN 15 MCG/ML TEK DOZLUK GOZ DAMLASI, 30 ADET, TAFLOTAN 15UG/MLHydrogen peroxide
go.drugbank.com/drugs/DB11091ApprovedInvestigationalVet approvedHydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. … Hydrogen peroxide is also considered as a generally recognized as safe compound by the FDA [L2024]; it is used as an antimicrobial agent in starch and cheese products, and as an oxidizing and reducing
Mixtures: K-100, K-100Products: OKSIJENLI SU, 150 ML, OKSIJENLI SU, 1000 MLGlycerin
go.drugbank.com/drugs/DB09462ApprovedInvestigationalA trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
Mixtures: MICROLAX LAVMAN, 10 G, AKE 1100 GLUKOZLU IV SOLOSYONU, 500 MLCategories: Cytochrome P-450 CYP2E1 Inducers, Cytochrome P-450 Enzyme InducersPlasma protein fraction (human)
go.drugbank.com/drugs/DB13968ApprovedInvestigationalThe composition of PPFh should be 5% of protein from which 83% should consist of albumin and no more of 17% should be globulin. … The plasma protein fraction human (PPFh) is defined as a sterile solution of proteins composed mainly of albumin and globulin derived from human plasma.
Mixtures: /ml InfusionslösungProducts: PLASMANATE - 5% (50 ML VIAL), PLASMANATE - 5% ( 250 ML VIAL )Amifostine
go.drugbank.com/drugs/DB01143ApprovedInvestigationalA phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Products: ETHYOL 500 MG IV INFUZYON ICIN LIYOFIZE TOZ ICEREN FLAKON, 1 ADET