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Displaying results 1431 - 1440 of 10000 in total
  1. Indication

    Ulceration of the mouth

    go.drugbank.com/conditions/DBCOND0100372
    Drugs: Apremilast · Benzethonium · Benzocaine · Choline salicylate · Dequalinium · Lidocaine +7 more
    Synonyms: Pain in oral cavity
  2. Drug

    Simoctocog alfa

    go.drugbank.com/drugs/DB09108
    Approved

    Simoctocog alfa is a fourth-generation BDD FVIII product made in the human embryonic kidney (HEK) cell line. … Full human post-translational modifications via elimination of potentially immunogenic glycosylation patterns found in non-human cell lines led to decreased immunogenicity and longer half-life [A31525]

  3. Drug

    Chlorthalidone

    go.drugbank.com/drugs/DB00310
    ApprovedInvestigational

    [A173863] In particular, the ALLHAT trial confirmed the role of thiazide diuretics as first-line therapy and demonstrated that chlorthalidone had a statistically significant lower incidence of stroke and … [A176324] Chlorthalidone is considered first-line therapy for management of uncomplicated hypertension as there is strong evidence from meta-analyses that thiazide diuretics such as chlorthalidone reduce

    Mixtures: ATENOLOLO E CLORTALIDONE MYLAN GENERICS, ATENOLOLO E CLORTALIDONE MYLAN GENERICSCategories: Heterocyclic Compounds, 2-Ring
  4. Target

    Voltage-gated Potassium Channels

    go.drugbank.com/bio_entities/BE0009847
    Target

    linear current-voltage relationship (By similarity) … Forms a heterooligomer complex with KCNQ1/KVLQT1 alpha subunits which leads to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship

    Polypeptides: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Synonyms: Potassium voltage-gated channel subfamily E member 1-like protein
  5. Drug

    Prilocaine

    go.drugbank.com/drugs/DB00750
    ApprovedInvestigational

    A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)

    Mixtures: LIDOCAINA E PRILOCAINA TEVA, LIDOCAINA E PRILOCAINA TEVASynonyms: N-(2-Methylphenyl)-2-(propylamino)propanamide, alpha-n-Propylamino-2-methylpropionanilide
  6. Drug

    Pemigatinib

    go.drugbank.com/drugs/DB15102
    ApprovedInvestigational

    exhibited gene rearrangements resulting in oncogenic fibroblast growth factor 2 (FGFR2) fusion proteins. … [A193719] FGFRs gained attention as potential therapeutic targets in selected cancers, as FGFR gene alterations were observed in a wide variety of cancers including those of the urinary bladder, breast

    Categories: MATE 1 Inhibitors, Cytochrome P-450 Substrates
  7. Drug

    Carbidopa

    go.drugbank.com/drugs/DB00190
    ApprovedInvestigational

    Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. … therapy developed by Mayne Pharma in 1992.

    Mixtures: LEV/CAR/EN AL100/25/200, LEV/CAR/EN AL200/50/200Categories: Aromatic L-amino Acid Decarboxylase Inhibitors
  8. Pathway

    Antrafenine Anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0124549
    Drug action

    Because antrafenine decrease PGE2 in the CNS, it has an antipyretic effect. … Prostaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase.

    Drugs: Glutathione · Dinoprostone · Calcium · Antrafenine · Mesoheme · Prostaglandin G2 +1 more
    Enzymes: Prostaglandin E synthase
  9. Pathway

    Nepafenac NSAID Action Pathway

    smpdb.ca/view/SMP0124581
    Drug action

    It targets the prostaglandin G/H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. … The cyclooxygenase pathway begins in the cytosol with phospholipids being converted into arachidonic acid by the action of phospholipase A2.

    Drugs: Glutathione · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 · Arachidonic Acid +2 more
    Enzymes: Prostaglandin E synthase
  10. Pathway

    Lornoxicam NSAID Action Pathway

    smpdb.ca/view/SMP0124587
    Drug action

    Prostaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase. … Cytokines are produced in the central nervous system (CNS) during an inflammatory response.

    Drugs: Glutathione · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 · Arachidonic Acid +1 more
    Enzymes: Prostaglandin E synthase