Prilocaine is a local anesthetic used in dental procedures. A local anesthetic that is similar pharmacologically to lidocaine.
- Mechanism
- Curator reviewed
Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
- Primary indication
- Used as a local anaesthetic and is often used in dentistry.Curator reviewed · 3 structured indications
- Formula / weight
- C13H20N2O · 220.3107 g/mol (avg)
- First approval
- Canada, 2009 · United States, 1965 · European Union, 2016
- Also known as
- Prilocaine base · Propitocaine
- Code names
- ASTRA-1512 · ASTRA-1515 · L 67
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
MVFGUOIZUNYYSO-UHFFFAOYSA-NSMILESCCCNC(C)C(=O)NC1=CC=CC=C1CTargets
What you can answer from here — as of September 11, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Prilocaine, and which of those have an active Phase 3 trial?
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