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Daclatasvir
go.drugbank.com/drugs/DB09102ApprovedInvestigationalWithdrawnIt exerts its antiviral action by preventing RNA replication and virion assembly via binding to NS5A, a nonstructural phosphoprotein encoded by HCV. … Daclatasvir is shown to target both the cis- and trans-acting functions of NS5A and disrupts the function of new HCV replication complexes by modulating the NS5A phosphorylation status [A19640].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: DASVIR 60 (DACLATASVIR TABLETS 60 MG), DAKLINZA 60 MG FILM KAPLI TABLET ,FILM KAPLI TABLET, 28 ADETSilibinin
go.drugbank.com/drugs/DB09298InvestigationalSilibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar ratio.
Products: SILIMARINA 150 MG, HEPABIONTAGRAGEAS 150 MGSulindac
go.drugbank.com/drugs/DB00605ApprovedInvestigationalSulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. … While its full mechanism of action is not fully understood, sulindac is thought to primarily mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and COX-2.
Synonyms: cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid, (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acidProducts: CLINORIL 200 MG TABLETAS, Sulindac-150 Tab 150mgStavudine
go.drugbank.com/drugs/DB00649ApprovedInvestigationalA dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
Mixtures: TRIVIRO LNS® LAMIVUDINA 150 MG NEVIRAPINA 200 MG ESTAVUDINA 40 MG, TRESLAM ® 30Products: ESTAVUDINA 40 MG, ESTAVUDINA 30 MGClevidipine
go.drugbank.com/drugs/DB04920ApprovedInvestigationalClevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: Cleviprex 0,5 mg/ml Emulsion zur InjektionSulfamethizole
go.drugbank.com/drugs/DB00576ApprovedVet approvedA sulfathiazole antibacterial agent.
Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: S- URISTIX 500 MG CAPSULAS, S*ORIPOL FORTE - SULFAMETIZOL 500 MG CAPSULASChloramphenicol succinate
go.drugbank.com/drugs/DB07565Approved[A204065] Use of chloramphenicol succinate and chloramphenicol has decreased due to the risk of potentially fatal blood dyscrasias. … [L14174] Chloramphenicol succinate was granted FDA approval on 20 February 1959.[L12711]
Products: GEMYSETIN SÜKSİNAT 1G I.M./ I.V. ENJEKSİYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN LİYOFİLİZE TOZ, 100 FLAKON, GEMYSETIN SÜKSİNAT 1G I.M./ I.V. ENJEKSİYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN LİYOFİLİZE TOZ, 1 FLAKONDoxofylline
go.drugbank.com/drugs/DB09273InvestigationalAs a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies. … Decreased affinity for adenosine receptors may account for the better safety profile of doxofylline compared to theophylline [L1169].
Mixtures: MUCOFIX 1200/400 MG EFERVESAN TABLET, 10 ADET, MUCOFIX 600/200 MG EFERVESAN, 10 ADETCategories: Phosphodiesterase 5 Inhibitors, Cytochrome P-450 SubstratesUlipristal
go.drugbank.com/drugs/DB08867ApprovedInvestigationalethical concerns related to abortion (Rosato et al, 2016). … It also binds to glucocorticoid receptor, however compared to mifepristone (a progesterone receptor antagonist), ulipristal is more tolerable and has lower glucocorticoid activity and better binding affinity
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ESMYA® 5 MG COMPRIMIDOS, Femke 30 mg FilmtabletteMagnesium salicylate
go.drugbank.com/drugs/DB01397ApprovedThough the recommended doseage is 1160 mg every six hours, per package directions of the Doan's OTC brand (580 mg magnesium salicylate tetrahydrate, equivalent to 934.4 mg anhydrous magnesium salicylate … Magnesium salicylate is a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain. It is available in several over-the-counter (OTC) formulations.
Products: Back-ese M Tablets 325 mg, Back-ese M Tab 325mg