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Displaying results 141 - 150 of 134146 in total
  1. Pathway

    Kidney Function- Proximal Convoluted Tubule

    smpdb.ca/view/SMP0121001
    Physiological

    In addition, chloride ions are not normally reabsorbed in large amounts at the proximal tubule compared to other parts of the nephron. … However, the reabsorption of chloride, as well as potassium, increases as the amount of water reabsorption increases due to solvent drag (also known as bulk transport).

    Drugs: Cysteine · Potassium cation · Zinc · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  2. Pathway

    Polythiazide Action Pathway

    smpdb.ca/view/SMP0000080
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Polythiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  3. Pathway

    Bendroflumethiazide Action Pathway

    smpdb.ca/view/SMP0000090
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Bendroflumethiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  4. Pathway

    Quinethazone Action Pathway (old)

    smpdb.ca/view/SMP0000091
    Drug action

    The short term mechanism of action is relatively well-understood: thiazides inhibit sodium-chloride co-transport into the renal distal convoluted tubule of the nephron and therefore increase fluid loss … In the case of quinethazone, it inhibits the sodium-chloride symporter, solute carrier family 12 member 3. Thiazides also inhibit sodium ion transport.

    Drugs: Cysteine · Quinethazone · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  5. Pathway

    Ethacrynic Acid Action Pathway

    smpdb.ca/view/SMP0000097
    Drug action

    Etacrynic acid (also known as ethacrynic acid and Edecrin) is a loop diuretic that can inhibit water reabsorption by binding and inhibiting solute carrier family 12 member 1 (also known as sodium-potassium-chloride … Binding of the transporter can prevent import of sodium from lumen from loop of Henle to basolateral interstitium, which lead to more hypertonic environment in lumen than interstitium, and result in prevention

    Drugs: Cysteine · Etacrynic acid · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  6. Pathway

    Hydrochlorothiazide Action Pathway

    smpdb.ca/view/SMP0000100
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Hydrochlorothiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  7. Pathway

    Indapamide Action Pathway

    smpdb.ca/view/SMP0000110
    Drug action

    Sodium-chloride symporter (also known as solute carrier family 12 member 3) can translocate chloride and sodium from lumen to epithelial cell. … Indapamide (also named as Noranat or Veroxil) is a thiazide-like diuretic drug that can be used to treat hypertension and decompensated heart failure.

    Drugs: Cysteine · Indapamide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  8. Pathway

    Amiloride Action Pathway

    smpdb.ca/view/SMP0000133
    Drug action

    Therefore, amiloride's inhibition of sodium reabsorption fails to produce an electrochemical gradient and therefore, inhibits potassium excretion. … Amiloride causes an increase in sodium excretion and a decrease in potassium secretion. The drug is typically prescribed to patients with depleted potassium.

    Drugs: Cysteine · Amiloride · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  9. Pathway

    Glucose Transporter Defect (SGLT2)

    smpdb.ca/view/SMP0000184
    Disease

    There are some drugs that inhibit SGLT2 and are used to decrease blood sugar in patients with type 2 diabetes mellitus. … It is responsible for approximately 90% of the kidney's reabsorption of glucose, and can be found in the S1 segment of the proximal convoluted tubule of the nephron.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  10. Pathway

    Hartnup Disorder

    smpdb.ca/view/SMP0000189
    Disease

    Symptoms include pellagra, psychosis, ataxia, and mental retardation. Treatment includes nicotinamide. … deficiency in this enzyme results in accumulation of L-alanine, L-asparagine, L-histidine, indoleacetic acid, L-isoleucine, L-leucine, L-phenylalanine, L-serine, L-threonine, L-tryptophan, L-valine, and

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka