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Digoxin Cardiac Action Pathway
smpdb.ca/view/SMP0125107Drug actionCommon side effects of digoxin include nausea, vomiting, and anorexia, rash, headache, gynecomastia and weakness. … Digoxin is a positive inotropic and negative chronotropic drug, meaning that it increases the force of the heartbeat and decreases the heart rate.
Enzymes: Sodium/calcium exchanger 1, Sodium/potassium-transporting ATPase subunit alpha-1Cocaine Analgesic Action Pathway
smpdb.ca/view/SMP0125257Drug actionIt comes in drugs called Goprelto and Numbrino which comes as a nasal spray. In these clinical drugs it takes the form of cocaine hydrochloride. The illicit drug has the same effects. … Primarily it acts on sensory neurons in the nasal cavity by inhibiting the sodium channels. Stimulation from touch, pressure, stretch, or pain causes sodium channels on sensory receptors to open.
Drugs: CocaineEnzymes: Sodium channel subunit beta-1, Sodium channel protein type 10 subunit alphaQuinethazone Action Pathway
smpdb.ca/view/SMP0123030Drug actionIn the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … In the cell, it has access to the Na+/Cl- transporter and inhibits it preventing Na+ and Cl- reabsorption.
Enzymes: Sodium/calcium exchanger 3, Sodium/potassium-transporting ATPase subunit alpha-1Indapamide Diuretic Action Pathway
smpdb.ca/view/SMP0123031Drug actionIn the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.
Enzymes: Sodium/calcium exchanger 3, Sodium/potassium-transporting ATPase subunit alpha-1Chlorothiazide Action Pathway
smpdb.ca/view/SMP0000078Drug actionSolute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATBumetanide Action Pathway
smpdb.ca/view/SMP0000088Drug actionIn the nephron, the think ascending limb reabsorbs 25% of sodium and is a good target for diuretics. … This results in the lumen becoming hypertonic and a decreased osmotic gradient thereby reducing the water reabsorption.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATCyclothiazide Action Pathway
smpdb.ca/view/SMP0000103Drug actionSolute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATMetolazone Action Pathway (old)
smpdb.ca/view/SMP0000105Drug actionSolute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATTorsemide Action Pathway
smpdb.ca/view/SMP0000118Drug actionThis prevents the reuptake of sodium into the Loop of Henle which consequentially reduces the uptake of water and serves to both increase water loss and reduce blood pressure. … It is commonly used to manage hypertension and edema in cases of congestive heart failure as it acts as a diuretic by blocking sodium transporters NKCC2 on the thick ascending limb of the Loop of Henle
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATChlorthalidone Action Pathway
smpdb.ca/view/SMP0000122Drug actionSolute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT