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Levamlodipine Action Pathway
smpdb.ca/view/SMP0126329Drug actionLevamlodipine is a calcium channel blocker used to treat hypertension. It can be found under the brand name Conjupri. Levamlodipine inhibits L-type calcium channels in vascular smooth muscle, reducing peripheral vascular resistance and b...
Nicardipine Action Pathway
smpdb.ca/view/SMP0126333Drug actionNicardipine is a calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. It can be found under the brand name Cardene. A potent calcium channel blockader with marked vasodilator action. It has...
Pinaverium Action Pathway
smpdb.ca/view/SMP0126336Drug actionPinaverium is a spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract. It can be found under the brand name Dicetel. Pinaverium is a spasmolytic agent used fo...
Verapamil Calcium Channel Vasodilation Action Pathway
smpdb.ca/view/SMP0126373Drug actionVerapamil, known as the brand names Calan, Isoptin, Tarka, and Verelan, is a non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. It is used for the treament of vasopastic angina, uns...
Sphingolipid Signaling (Receptor)
smpdb.ca/view/SMP0524344SignalingSphingosine‑1‑phosphate (S1P) is a potent bioactive lipid mediator synthesized intracellularly by the phosphorylation of sphingosine by sphingosine kinases SphK1 and SphK2 at the plasma membrane and is then exported via spinster 2 (SPNS2...
Gemcitabine Action Pathway (old)
smpdb.ca/view/SMP0000446Drug actionGemcitabine is a cytidine analogue used in the treatment of certain cancers. Gemcitabine enters the cell via sodium nucleoside co-transporters (SLC29A1, SLC28A1, and SLC28A3), where it acts through multiple mechanisms to produce a cytoto...
Grazoprevir Action Pathway
smpdb.ca/view/SMP0125958Drug actionGrazoprevir is an antiviral and non-structural 3/4A protease inhibitor used to treat hepatitis C infections in combination with other drugs. Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis. ...
Nimodipine Action Pathway (New)
smpdb.ca/view/SMP0126299Drug actionNimodipine is a calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm. It can be found under the brand names Nimotop and Nymalize. Nimodipine is a 1...
Nisoldipine Action Pathway (New)
smpdb.ca/view/SMP0126300Drug actionNisoldipine is a calcium channel blocker used as monotherapy or combined with other drugs for the treatment of hypertension. It can be found under the brand name Sular. Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It act...
Manidipine Action Pathway
smpdb.ca/view/SMP0126330Drug actionManidipine is a dihydropyridine calcium channel blocker used to treat hypertension. It is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages. C...