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Displaying results 141 - 150 of 597 in total
  1. Pathway

    Flecainide Action Pathway

    smpdb.ca/view/SMP0000331
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: ATP · Flecainide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  2. Pathway

    Ibutilide Action Pathway

    smpdb.ca/view/SMP0000332
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … The extra sodium and calcium ions that entered the cell during the action potential are extruded via sodium-potassium ATPases and NCX and intra- and extracellular ion concentrations are restored.

    Drugs: ATP · Ibutilide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  3. Pathway

    Esmolol Action Pathway

    smpdb.ca/view/SMP0000301
    Drug action

    Normally, epinephrine and norepinephrine bind to the beta-1 adrenergic receptor with equal affinity and trigger a G-protein signalling cascade that result in the heart muscle contracting. … Esmolol is injected intravenously, and when it enters the heart, it binds to the beta-1 adrenergic receptor, preventing signalling.

    Drugs: ATP · Esmolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  4. Pathway

    Labetalol Action Pathway

    smpdb.ca/view/SMP0000368
    Drug action

    Labetalol (also known as Albetol or Ibidomide) is an inhibitor/antagonist of beta-1 adrenergic receptor that can be used for treating high blood pressure and reducing cardiac output. … Labetalol can bind to beta-1 adrenergic receptor on both vascular smooth muscle, which lead to inhibition of vasoconstriction in peripheral blood vessels and adrenergic stimulation of endothelial cell

    Drugs: ATP · Labetalol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  5. Pathway

    Felodipine Action Pathway

    smpdb.ca/view/SMP0000377
    Drug action

    High sodium intake can contribute to hypertension. … Hypertension is a very common condition in North America, and can be managed with medication, diet and a healthy lifestyle.

    Drugs: ATP · Felodipine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  6. Pathway

    Sotalol Action Pathway

    smpdb.ca/view/SMP0000660
    Drug action

    Sotalol inhibits response to adrenergic stimuli by competitively blocking β1-adrenergic receptors within the myocardium and β2-adrenergic receptors within bronchial and vascular smooth muscle. … The electrophysiologic effects of sotalol may be due to its selective inhibition of the rapidly activating component of the potassium channel involved in the repolarization of cardiac cells.

    Drugs: ATP · Sotalol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  7. Pathway

    Epinephrine Action Pathway

    smpdb.ca/view/SMP0000661
    Drug action

    Epinephrine can be derived from phenylalanine and tyrosine and it is an active sympathomimetic hormone that can be secreted from adrenal medulla. … raise up blood sugar level and breaking down lipids in adipocytes.

    Drugs: ATP · Epinephrine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  8. Pathway

    Acebutolol Action Pathway

    smpdb.ca/view/SMP0000296
    Drug action

    Adrenaline (also known as epinephrine) can activate β1 adrenergic receptor so that the heart rate and output will be increased. … Acebutolol (also known as Sectral or Prent) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats

    Drugs: ATP · Acebutolol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  9. Pathway

    Penbutolol Action Pathway

    smpdb.ca/view/SMP0000305
    Drug action

    , heart rate and cardiac output. … In juxtaglomerular apparatus, penbutolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction.

    Drugs: ATP · Potassium cation · Penbutolol · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1
  10. Pathway

    Carvedilol Action Pathway

    smpdb.ca/view/SMP0000367
    Drug action

    Its activity decreases heart rate, myocardial contractility and oxygen demand and decreases vascular resistance. … Carvedilol, trade name Coreg, is a nonselective beta-blocker that blocks both alpha and beta receptors of the heart and blood vessels.

    Drugs: ATP · Carvedilol · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-transporting ATPase subunit alpha-1