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Displaying results 141 - 150 of 1717 in total
  1. Drug

    LNS-8801

    go.drugbank.com/drugs/DB18091
    Investigational

    Synonyms: G 1 (g protein-coupled estrogen receptor agonist), Ethanone, 1-((3ar,4s,9bs)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)-, rel-
  2. Drug

    Bexagliflozin

    go.drugbank.com/drugs/DB12236
    ApprovedInvestigational

    Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor. … [A256423,L44758] In January 2023, bexagliflozin was approved by the FDA for the treatment of adults with type 2 diabetes.

    Synonyms: D-glucitol, 1,5-anhydro-1-C-(4-chloro-3-((4-(2-(cyclopropyloxy)ethoxy)phenyl)methyl)phenyl)-, (1s)-, (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(cyclopropyloxy)ethoxy)phenyl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triolCategories: Sodium-Glucose Transport Proteins, antagonists & inhibitors, P-glycoprotein substrates
  3. Drug

    Exagamglogene autotemcel

    go.drugbank.com/drugs/DB15572
    ApprovedInvestigational

    Sickle cell disease (SCD) is a genetic disorder characterized by the production of abnormal sickle-shaped red blood cells (called hemoglobin S, HbS) that initiate a pathophysiology resulting in severe … [L10139] Following engraftment, it causes an increase in the production of HbF and a subsequent decrease in HbS.

    Synonyms: Autologous CD34+ cells isolated from mobilised peripheral blood by positive selection, modified by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) mediated, gene editing consisting of a guide RNA (gRNA)
  4. Drug

    Deslanoside

    go.drugbank.com/drugs/DB01078
    Approved

    Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.

    Categories: Compounds used in a research, industrial, or household settingSynonyms: Deacetyllanatoside C, Desacetyllanatoside C
  5. Drug

    Verpasep caltespen

    go.drugbank.com/drugs/DB04959
    Investigational

    Verpasep caltespen is a recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from _Mycobacterium bovis_, and the human papilloma viral (HPV) protein E7. … E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen that may be specifically targeted by lymphocytes.

    Synonyms: Heat-shock protein HSP 65 (Mycobacterium BCG) fusion protein with transcription factor E7 (human papillomavirus 16), Recombinant fusion protein of Mycobacterium bovis BCG Hsp65 and HPV16 E7
  6. Drug

    Zalifrelimab

    go.drugbank.com/drugs/DB15632
    Investigational

    Zalifrelimab is under investigation in clinical trial NCT03894215 (Phase 2 Study of Anti-pd-1 Independently or in Combination With Anti-ctla-4 in Second-line Cervical Cancer).

    Synonyms: A human monoclonal antibody targeting cytotoxic T lymphocyte associated protein 4 (ctla4), Immunoglobulin G1-kappa, anti-(homo sapiens CTLA4 (cytotoxic tlymphocyte-associated protein 4, cd152))
  7. Drug

    Chelerythrine

    go.drugbank.com/drugs/DB17024
    Experimental

    A benzophenanthridine alkaloid evaluated as a kinase-inhibitor.[A252982]

    Categories: Protein Kinase C, antagonists & inhibitors, Heterocyclic Compounds, 3-RingSynonyms: 1,2-dimethoxy-12-methyl(1,3)dioxolo)4',5':4,5)benzo(1,2-c)phenanthridinium, (1,3)benzodioxolo(5,6-c)phenanthridinium, 1,2-dimethoxy-12-methyl-
  8. Drug

    Nemvaleukin alfa

    go.drugbank.com/drugs/DB18187
    Investigational

    Synonyms: 75-133-interleukin 2 (125-serine) (human) fusion protein with peptide linker (gg) fusion protein with 4-74-interleukin 2 (human) fusion protein with peptide linker (gsgggs) fusion protein with 1-165-interleukin, 75-133-Interleukin 2 [125-serine] (human) fusion protein with peptide linker (GG) fusion protein with 4-74-interleukin 2 (human) fusion protein with peptide linker (GSGGGS) fusion protein with 1-165-interleukin
  9. Drug

    Telitacicept

    go.drugbank.com/drugs/DB18312
    Investigational

    Synonyms: (1-106) FUSION PROTEIN WITH HUMAN IMMUNOGLOBULIN G1, 13-118-tumor necrosis factor receptor superfamily protein tnfrsf13b (human extracellular domain fragment) fusion protein with immunoglobulin g1, (human rc18 fc fragment), dimerCategories: Proteins, Recombinant Proteins
  10. Drug

    A-dmDT390-bisFv(UCHT1)

    go.drugbank.com/drugs/DB16307
    Investigational

    A-dmDT390-bisFv(UCHT1) is under investigation in clinical trial NCT02943642 (Safety and Effectiveness of A-dmdt390-bisfv(ucht1) Fusion Protein in Subjects With Mycosis Fungoides).

    Synonyms: Recombinant anti-cdr-bi-single-chain-fv-diphtheria toxin fusion protein, Recombinant anti-cdr-bi-single-chain-fv-diptheria toxin fusion protein