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Glasdegib
go.drugbank.com/drugs/DB11978ApprovedInvestigational[A258498,A258503] Although the efficacy of glasdegib monotherapy is limited, the landmark Phase 2 Bright AML 1003 trial showed a superior overall survival and complete response when glasdegib is combined … Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsLomefloxacin
go.drugbank.com/drugs/DB00978ApprovedLomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs).
Categories: Topoisomerase II Inhibitors, 4-QuinolonesSynonyms: (±)-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acidBromotheophylline
go.drugbank.com/drugs/DB14018ApprovedBromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. … [A33018] Bromotheophylline is categorized on the FDA as a drug substance with an inactive state since March, 1980.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingSynonyms: 8-BromotheophyllineNS-2359
go.drugbank.com/drugs/DB05805InvestigationalNS2359 is a triple monoamine re-uptake inhibitor with a new, unique drug profile expected to yield important benefits compared to existing treatments of depression. … This mode of action is expected to produce an optimal reduction in all disease symptoms and the possibility of an earlier onset of action compared to antidepressants already on the market.
Hydrochlorothiazide
go.drugbank.com/drugs/DB00999ApprovedInvestigationalVet approvedHydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension. … [A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.
Mixtures: Combi-SIG, METOPROLOL HCT S 100/12.5Categories: Heterocyclic Compounds, 2-RingXanthinol
go.drugbank.com/drugs/DB09092ApprovedWithdrawnXanthinol is a very potent water-soluble derivative of niacin that can be found in diet supplements. It is also known as xanthinol nicotinate. … [L1080] It was approved as a drug in 1998 in Canada and nowadays its status is cancelled post marketing.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingBrinzolamide
go.drugbank.com/drugs/DB01194ApprovedBrinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase II (CA-II) inhibitor indicated to reduce ocular pressure in patients with ocular hypertension or open-angle glaucoma. … [L35310] Although the exact pathophysiology of glaucoma is still unknown, one of the main hallmarks of this disease is vascular dysregulation and abnormalities.
Mixtures: BRİTİL-T 10 MG/ML + 5 MG/ML GÖZ DAMLASI, SÜSPANSİYON, 1 ADET, BRIDINE®Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesRifamycin
go.drugbank.com/drugs/DB11753ApprovedInvestigationalWithdrawnRifamycin is the prime member of the rifamycin family which are represented by drugs that are a product of fermentation from the gram-positive bacterium _Amycolatopsis mediterranei_, also known as _Streptomyces … [A39990] Rifamycin has had several direct derivative products such as rifamycin SV, rifaximin, rifampin and rifamycin CV.
Mixtures: RIFETEM 250 MG / 3 ML AMPUL, 1 ADET, RİF 250 MG/3 ML IM ENJEKSİYONLUK ÇÖZELTİ (1 AMPUL)Categories: MATE 1 Inhibitors, P-glycoprotein inhibitorsDidesmethylrocaglamide
go.drugbank.com/drugs/DB15496ExperimentalDidesmethylrocaglamide is a naturally-occurring derivative of [rocaglamide] and belongs to a class of anti-cancer phytochemicals referred to as "rocaglamides" derived from plants of the genus _Aglaia_. … [A186760] While traditionally used for their insecticidal benefits,[A186796] this class of compounds is now being studied for use as chemotherapeutic agents in the treatment of various leukemias, lymphomas
Technetium Tc-99m tetrofosmin
go.drugbank.com/drugs/DB09160ApprovedTechnetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. … It is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit which yields an injection.
Categories: P-glycoprotein substrates, Compounds used in a research, industrial, or household setting