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Fexinidazole
go.drugbank.com/drugs/DB12265ApprovedHuman African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by _T. brucei gambiense_ and _T. brucei rhodesiense_, remains a moderate risk (>1/10,000 inhabitants per … Transmitted by the bite of an infected tsetse fly, HAT is biphasic with a first (hemolymphatic) stage that progresses to a second (meningoencephalitic) stage in which patients experience progressively
Categories: MATE 2-K Inhibitors, MATE 1 InhibitorsEpofolate
go.drugbank.com/drugs/DB12266InvestigationalEpofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target folate receptor expressing cancer cells. … In Phase I/IIa pharmacokinetic and safety studies epofolate was generally tolerable and toxicities known to be associated with epothilone class of anticancer agents were common, although peripheral neuropathy
Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 2-RingAducanumab
go.drugbank.com/drugs/DB12274ApprovedInvestigationalin amyloid-β plaques. … Aducanumab, or BIIB037, is a monoclonal IgG1 antibody that targets extracellular amyloid-β plaques in the brain; similar to [gantenerumab], [bapineuzumab] and [solanezumab].
Polihexanide
go.drugbank.com/drugs/DB12277ApprovedInvestigational[A1351] It is effective against a wide range of Gram-positive and Gram-negative bacteria. … Polihexanide, also known as polyhexamethylene biguanide (PHMB), is a broad-spectrum antimicrobial polymer primarily used for topical antisepsis and wound management.
Mixtures: Ucheer CCategories: Compounds used in a research, industrial, or household settingAZD-5423
go.drugbank.com/drugs/DB12280InvestigationalAZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD).
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingDarexaban
go.drugbank.com/drugs/DB12289InvestigationalDarexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.
Categories: Heterocyclic Compounds, 1-Ring5-Hydroxymethylfurfural
go.drugbank.com/drugs/DB12298InvestigationalAes-103 has been used in trials studying the treatment and prevention of Hypoxia, Anemia, Sickle Cell, and Sickle Cell Disease.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-(hydroxymethyl)-2-furaldehyde, 5-(Hydroxymethyl)-2-furfuralBavisant
go.drugbank.com/drugs/DB12299InvestigationalBavisant has been used in trials studying the basic science and treatment of Alcoholism, Pharmacokinetics, Drug Interactions, Attention Deficit Hyperactivity Disorder, and Attention Deficit Disorders With Hyperactivity.
Categories: Heterocyclic Compounds, 1-RingRadotinib
go.drugbank.com/drugs/DB12323InvestigationalRadotinib is under investigation for the treatment of Leukemia, Myelogenous, Chronic, BCR-ABL Positive.
Categories: Heterocyclic Compounds, 1-RingAticaprant
go.drugbank.com/drugs/DB12341InvestigationalAticaprant has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence.
Synonyms: BENZAMIDE, 4-(4-(((2S)-2-(3,5-DIMETHYLPHENYL)-1-PYRROLIDINYL)METHYL)PHENOXY)-3-FLUORO-Categories: Heterocyclic Compounds, 1-Ring