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Cabozantinib
go.drugbank.com/drugs/DB08875ApprovedInvestigationalCabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. … It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsProducts: CABOMETYX 20 MG FİLM KAPLI TABLET, 30 ADET, CABOMETYX 40 MG FİLM KAPLI TABLET, 30 ADETVerteporfin
go.drugbank.com/drugs/DB00460ApprovedInvestigationalVerteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: [CL-315555] and [CL-315585]. … It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration.
Products: VISUDYNE FOR INJECTION 15 mg/vial, VISUDYNE 15 MG INFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZAsciminib
go.drugbank.com/drugs/DB12597ApprovedInvestigational[L38995,A241055] Asciminib received FDA approval on October 29, 2021 (Scemblix, Novartis AG).[L39000] … [L39005] It has also shown benefit in Ph+ CML with the T315I mutation, which produces a mutant BCR-ABL1 which is typically treatment-resistant as compared to wild-type BCR-ABL1.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 InhibitorsProducts: AZEVAY 20 MG FİLM KAPLI TABLET , 60 ADET, AZEVAY 40 MG FİLM KAPLI TABLET , 60 ADETTropisetron
go.drugbank.com/drugs/DB11699ApprovedInvestigationalWithdrawnAs a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting
Categories: Serotonin 5-HT3 Receptor Antagonists, Cytochrome P-450 SubstratesProducts: NAVOBAN 5 MG 1 AMPUL, Navoban 5 mg - AmpullenMeclizine
go.drugbank.com/drugs/DB00737ApprovedInvestigational[L6760] Commonly marketed under the brand name Antivert in the U.S., meclizine is available as oral tablets.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesProducts: Meclizine HCl 25 mg, Meclizine HCL 25 mgBromazepam
go.drugbank.com/drugs/DB01558ApprovedIllicitOne of the benzodiazepines that is used in the treatment of anxiety disorders. It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. It is a intermediate-acting benzodiazepine.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: LEXOTAN TABLET 3 mg, Lexotanil 3 mg - TablettenCobimetinib
go.drugbank.com/drugs/DB05239ApprovedInvestigationalIt has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of patients with unresectable or metastatic BRAF V600 mutation-positive melanoma. … Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsProducts: COTELLIC FILM-COATED TABLET 20 MG, COTELLIC® (COBIMETINIB) 20 MG TABLETAS RECUBIERTASRibociclib
go.drugbank.com/drugs/DB11730ApprovedInvestigationalRibociclib was approved by the FDA in March 2017 under the brand name Kisqali.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: KISQALI (200 MG), KISQALI 200 MG TABLETAS RECUBIERTASGadobenic acid
go.drugbank.com/drugs/DB00743ApprovedInvestigationalGadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver. … [A1139] Gadobenate dimeglumine was approved by the FDA in November 2004 under the brand name MultiHance.[A263166]
Mixtures: MULTIHANCE INJECTION 10 ML, MULTIHANCE INJECTION 10 MLProducts: MULTIHANCE TEK DOZLUK IV ENJEKSIYONLUK COZELTI ICEREN FLAKON, 10 ML, MULTIHANCE INJECTION 20 MLPrednicarbate
go.drugbank.com/drugs/DB01130ApprovedIt is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. … Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as [hydrocortisone].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: DERMATOP 2.5 MG/G KREM, 30 G, DERMATOP 2.5 MG/G MERHEM, 30 G