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Cladribine
go.drugbank.com/drugs/DB00242ApprovedInvestigationalCladribine is a purine analogue or a chlorinated derivative of adenine that causes apoptosis of B and T lymphocytes. Cladribine was first approved in the United States in 1993 initially as a treatment for a number of hematological malign...
Categories: P-glycoprotein substratesRanolazine
go.drugbank.com/drugs/DB00243ApprovedInvestigationalChronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of t...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: RANOLAZINA DOC GENERICIBenzatropine
go.drugbank.com/drugs/DB00245ApprovedInvestigationalBenztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocain...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesCabergoline
go.drugbank.com/drugs/DB00248ApprovedInvestigationalCabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesDiethylstilbestrol
go.drugbank.com/drugs/DB00255ApprovedWithdrawnA synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), dieth...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesDicoumarol
go.drugbank.com/drugs/DB00266ApprovedDicoumarol is an oral anticoagulant agent that works by interfering with the metabolism of vitamin K. In addition to its clinical use, it is also used in biochemical experiments as an inhibitor of reductases.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesIsradipine
go.drugbank.com/drugs/DB00270ApprovedIsradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blo...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesDisopyramide
go.drugbank.com/drugs/DB00280ApprovedInvestigationalA class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also po...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesRopivacaine
go.drugbank.com/drugs/DB00296ApprovedInvestigationalRopivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: ROPIVACAINA MYLAN GENERICSFilapixant
go.drugbank.com/drugs/DB21467ExperimentalFilapixant is a small molecule drug. The usage of the INN stem '-pixant' in the name indicates that Filapixant is a purinoreceptor (P2X) antagonist. Filapixant has a monoisotopic molecular weight of 521.17 Da.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates