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Displaying results 1571 - 1580 of 1640 in total
  1. Drug

    Esomeprazole

    go.drugbank.com/drugs/DB00736
    ApprovedInvestigational

    [A177577, A177580] Due to their good safety profile and as several PPIs are available over the counter without a prescription, their current use in North America is widespread.

  2. Drug

    Gantenerumab

    go.drugbank.com/drugs/DB12034
    Investigational

    Gantenerumab binds to a unique Aβ epitope compared to other anti-Aβ antibodies and preferentially recognizes Aβ oligomers and fibrils over monomers.[A244720]

  3. Target

    Transforming growth factor beta activator LRRC32

    go.drugbank.com/bio_entities/BE0014554
    TargetHumans

    Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed:19750484, PubMed:22278742). As...

    Synonyms: Leucine-rich repeat-containing protein 32Function: receptor ligand inhibitor activity
  4. Drug

    Carbon monoxide

    go.drugbank.com/drugs/DB11588
    ApprovedInvestigational

    There have been several concerns voiced of over the use of carbon monoxide in food products [L2537], [L2538], [L2539].

  5. Target

    T-lymphocyte activation antigen CD80

    go.drugbank.com/bio_entities/BE0000847
    TargetHumans

    Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed:10583602, PubMed:11279502). … Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:

    Synonyms: CTLA-4 counter-receptor B7.1
  6. Target

    Small ribosomal subunit protein RACK1

    go.drugbank.com/bio_entities/BE0008967
    TargetHumans

    Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L.

    Synonyms: Receptor for activated C kinase, Receptor for activated C kinase 1
  7. Target

    T-lymphocyte activation antigen CD86

    go.drugbank.com/bio_entities/BE0000846
    TargetHumans

    Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed:11279501) … Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:

    Synonyms: CTLA-4 counter-receptor B7.2
  8. Target

    Integrin beta-1

    go.drugbank.com/bio_entities/BE0003575
    TargetHumans

    Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. … ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).

    Synonyms: Fibronectin receptor subunit beta
  9. Target

    Serine/threonine-protein kinase TNNI3K

    go.drugbank.com/bio_entities/BE0009401
    TargetHumans

    May play a role in cardiac physiology

    Synonyms: Cardiac ankyrin repeat kinase
  10. Target

    Protein arginine N-methyltransferase 1

    go.drugbank.com/bio_entities/BE0004597
    TargetHumans

    May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator

    Synonyms: Interferon receptor 1-bound protein 4