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Respiratory syncytial virus vaccine, adjuvanted
go.drugbank.com/drugs/DB17762ApprovedInvestigational[L46347] On May 3, 2023, it was approved by the FDA for immunization against lower respiratory tract disease (LRTD) as the first respiratory syncytial virus (RSV) vaccine approved in the United States … Arexvy (respiratory syncytial virus vaccine, adjuvanted) is an adjuvanted vaccine developed by GlaxoSmithKline Biologicals.
Palovarotene
go.drugbank.com/drugs/DB05467ApprovedTreatment options for patients with FOP are extremely limited, although there has been substantial recent interest in novel treatments for this disease. … Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder.
Categories: Retinoic Acid Receptor gamma, agonists, Cytochrome P-450 SubstratesDebrisoquine
go.drugbank.com/drugs/DB04840ApprovedAn adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. … Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs.
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates16-Bromoepiandrosterone
go.drugbank.com/drugs/DB05107InvestigationalIt is a chemical relative of DHEA which was selected for development after it showed antiretroviral activity in laboratory tests. … 16-Bromoepiandrosterone is an injectable formulation of a compound called alpha-epi-bromide.
Fluorodopa (18F)
go.drugbank.com/drugs/DB13848ApprovedInvestigationalFluorodopa F 18 is a fluorinated analog of [levodopa] used as a diagnostic agent for positron emission tomography (PET) in the evaluation of Parkinsonian syndromes.
Products: IASOdopa 0,3 GBq/ml - Konzentrat zur Herstellung einer InjektionslösungTemazepam
go.drugbank.com/drugs/DB00231ApprovedUnfortunately, however, given its frequent use and the inherent nature of its pharmacological effects, temazepam - like many other benzodiazepines - possesses a high potential for misuse and is genuinely … Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesCefaloridine
go.drugbank.com/drugs/DB09008ApprovedWithdrawnIt is derived from cephalosporin C and is a zwitterion at physiological pH.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseAdenosine receptor A1
go.drugbank.com/bio_entities/BE0000013TargetHumansReceptor for adenosine (PubMed:29925945). The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase
Polypeptides: Adenosine receptor A1Function: G protein-coupled adenosine receptor activityHistamine H2 receptor
go.drugbank.com/bio_entities/BE0000112TargetHumansG protein-coupled receptor for histamine, primarily mediating gastric acid secretion. … Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release (By similarity)
Polypeptides: Histamine H2 receptorSynonyms: Gastric receptor IHistamine H4 receptor
go.drugbank.com/bio_entities/BE0000146TargetHumansG protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses (PubMed
Polypeptides: Histamine H4 receptorSynonyms: G protein-coupled receptor 105