Histamine H2 receptor

BE0000112ProteinHumansHRH2

G protein-coupled receptor for histamine, primarily mediating gastric acid secretion. It is acted on by 40 drugs in DrugBank.

Gene name
HRH2
UniProtKB entry
P25021Swiss-Prot
Cellular location
Cell membrane
Residues / weight
359 residues · 40,098 Da
Also known as
Gastric receptor I · H2R · HH2R

Resolves to

Protein
UniProtP25021UniProt nameHRH2_HUMAN
Gene
HGNCHGNC:5183NCBI Gene3274GenBank184088GeneCardsHRH2
Pharmacology
IUPHAR/GtoPdb263KEGGhsa:3274
Structure
PDB7UL3PDB8POKPDB8YN3
Drugs

What you can answer from here — as of September 07, 2019

40DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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134+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histamine H2 receptor, how selective are they, and which programs against it are still in active trials?

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