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Displaying results 1581 - 1590 of 10000 in total
  1. Drug

    Cysteamine

    go.drugbank.com/drugs/DB00847
    ApprovedInvestigational

    Cystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome. … [L15611] On August 25th 2020, the first ophthalmic solution for cystinosis requiring only 4 daily treatments was granted FDA approval.

    Synonyms: 2-amino-1-ethanethiol, β-MEAProducts: CYSTAGON ® 150 MG, CYSTAGON ® 50 MG CAPSULAS
  2. Drug

    Umeclidinium

    go.drugbank.com/drugs/DB09076
    ApprovedInvestigational

    Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). … COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory volume in 1 second (FEV1) of less than

    Synonyms: 1-[2-(benzyloxy)ethyl]-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octaneMixtures: ANORO ELLIPTA 62.5 MCG + 25 MCG KULLANIMA HAZIR INHALASYON TOZU, 3 X 30 DOZ, TRELEGY ELLIPTA INHALATION POWDER 100 MCG/62.5 MCG/25 MCG
  3. Drug

    Methocarbamol

    go.drugbank.com/drugs/DB00423
    ApprovedInvestigationalVet approved

    Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether. … [Label,L6268] In Canada, methocarbamol can be sold as an over the counter oral medicine at a lower dose that may be combined with [acetaminophen] or [ibuprofen].

    Synonyms: (RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamateMixtures: SINAXAR ® A TABLETAS, METOCARBAMOL 500 MG + IBUPROFENO 200 MG TABLETAS RECUBIERTAS
  4. Drug

    Arsenic trioxide

    go.drugbank.com/drugs/DB01169
    ApprovedInvestigational

    In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. … The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsProducts: LEUSENOX 10 MG/10 ML IV INFÜZYON IÇIN KONSANTRE ÇÖZELTI IÇEREN AMPUL, 1 ADET, TRISENOX 1 MG/1 ML IV INFÜZYON IÇIN KONSANTRE ÇÖZELTI IÇEREN AMPUL, 10 ADET
  5. Drug

    Calcitriol

    go.drugbank.com/drugs/DB00136
    ApprovedInvestigationalNutraceutical

    of classical nuclear receptors (nVDR), where calcitriol acts as a natural ligand [A175615]. … Calcitriol plays a role in plasma calcium regulation in concert with parathyroid hormone (PTH) by enhancing absorption of dietary calcium and phosphate from the gastrointestinal tract, promoting renal

    Synonyms: 1-alpha-25-Dihydroxyvitamin D3Categories: Vitamin D and Analogues, Cytochrome P-450 Substrates
  6. Drug

    Sulindac

    go.drugbank.com/drugs/DB00605
    ApprovedInvestigational

    Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. … Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril.

    Synonyms: (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid, cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acidCategories: Non COX-2 selective NSAIDS
  7. Drug

    Nifuroxazide

    go.drugbank.com/drugs/DB13855
    Investigational

    Mixtures: METRONIDAZOL/NIFUROXAZIDA 300 MG/100 MG., METRO F 400 CÁPSULASCategories: Heterocyclic Compounds, 1-Ring
  8. Drug

    Pilocarpine

    go.drugbank.com/drugs/DB01085
    ApprovedInvestigational

    A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist. … The usage of glaucoma by pilocarpine dates back to 1875.[A262041]

    Synonyms: 2(3H)-FURANONE, 3-ETHYLDIHYDRO-4-((1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-, (3S-CIS)-Mixtures: E-pilo-2 Oph Soln, E-pilo-6 Oph Soln
  9. Drug

    Artesunate

    go.drugbank.com/drugs/DB09274
    ApprovedInvestigational

    [L890] Artesunate was developed out of a need for a more hydrophilic derivative of [artemisinin].[A203948] Artesunate was granted FDA approval on 26 May 2020.[L14099] … [L14099] The World Health Organization recommends artesunate as first line treatment for severe malaria.

    Synonyms: butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester, ASMixtures: อาร์ทีซูเนทและเมฟลอควินไฮโดรคลอไรด์ 100/220 มก.
  10. Drug

    Ebastine

    go.drugbank.com/drugs/DB11742
    ApprovedInvestigationalWithdrawn

    Ebastine is under investigation for the treatment of Irritable Bowel Syndrome (IBS). Ebastine has been investigated for the treatment of Urticaria.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: PINAVALT® 10 MG TABLETASRECUBIERTAS, EBAFIT 20 MG FILM KAPLI TABLET, 10 ADET