Search

Displaying results 151 - 160 of 160885 in total
  1. Pathway

    Trehalose Degradation

    smpdb.ca/view/SMP0000467
    Metabolic

    Trehalose, also known as mycose or tremalose, is a sugar consisting of two 1-1 alpha bonded glucose molecules. … These are then transported into the epithelial cells along with a sodium ion by a sodium/glucose cotransporter, which can bring glucose up its gradient along with sodium moving down its gradient.

    Drugs: ATP · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  2. Pathway

    Lactose Intolerance

    smpdb.ca/view/SMP0125808
    Disease

    Lactase deficiency is most prevalent in Asia, Africa and Indigenous populations in North and South America. … The symptoms of lactose intolerance include diarrhea, bloating, abdominal pain and excessive flatus.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  3. Pathway

    Kidney Function - Collecting Duct

    smpdb.ca/view/SMP0121011
    Physiological

    In addition, sodium and potassium are also reabsorbed back into the systemic circulation at the collecting duct via potassium and sodium channels. … As a result, a high concentration of sodium and potassium in the blood vessels occurs. Some urea and other ions may be reabsorbed as well.

    Drugs: Potassium cation · Zinc · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Amiloride-sensitive sodium channel subunit alpha
  4. Pathway

    Pantoprazole Action Pathway

    smpdb.ca/view/SMP0123293
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … Sulfenamide then covalently binds to the cysteine residues on the alpha subunit of the H+/K+ ATPase via disulfide bridges.

    Drugs: Pantoprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  5. Pathway

    Omeprazole Action Pathway

    smpdb.ca/view/SMP0122674
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … Sulfenamide then covalently binds to the cysteine residues on the alpha subunit of the H+/K+ ATPase via disulfide bridges.

    Drugs: Omeprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  6. Pathway

    Esomeprazole Action Pathway

    smpdb.ca/view/SMP0123196
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … Sulfenamide then covalently binds to the cysteine residues on the alpha subunit of the H+/K+ ATPase via disulfide bridges.

    Drugs: Esomeprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  7. Pathway

    Lansoprazole Action Pathway

    smpdb.ca/view/SMP0123261
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … Sulfenamide then covalently binds to the cysteine residues on the alpha subunit of the H+/K+ ATPase via disulfide bridges.

    Drugs: Lansoprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  8. Pathway

    Rabeprazole Antacid Action Pathway

    smpdb.ca/view/SMP0123294
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … Sulfenamide then covalently binds to the cysteine residues on the alpha subunit of the H+/K+ ATPase via disulfide bridges.

    Drugs: Rabeprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  9. Pathway

    Digoxin Cardiac Action Pathway

    smpdb.ca/view/SMP0125107
    Drug action

    Common side effects of digoxin include nausea, vomiting, and anorexia, rash, headache, gynecomastia and weakness. … Digoxin is a positive inotropic and negative chronotropic drug, meaning that it increases the force of the heartbeat and decreases the heart rate.

    Drugs: Digoxin · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  10. Pathway

    Torasemide Action Pathway (New)

    smpdb.ca/view/SMP0124537
    Drug action

    Torasemide binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … The K+/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell into the peritubular fluid.

    Drugs: Torasemide · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3