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Displaying results 151 - 160 of 134502 in total
  1. Pathway

    Betaxolol Action Pathway

    smpdb.ca/view/SMP0000299
    Drug action

    Blocking of beta1-adrenergic receptors in heart and vascular smooth muscle can lead to reduced heart rate, cardiac output, and decreased blood pressure. … Betaxolol (also known as Betoptic or Lokren) is a selective beta blocker that can block beta1-adrenergic receptors and beta2-adrenergic receptors.

    Drugs: ATP · Betaxolol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  2. Pathway

    Esmolol Action Pathway

    smpdb.ca/view/SMP0000301
    Drug action

    Normally, epinephrine and norepinephrine bind to the beta-1 adrenergic receptor with equal affinity and trigger a G-protein signalling cascade that result in the heart muscle contracting. … Esmolol is injected intravenously, and when it enters the heart, it binds to the beta-1 adrenergic receptor, preventing signalling.

    Drugs: ATP · Esmolol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  3. Pathway

    Nadolol Action Pathway

    smpdb.ca/view/SMP0000303
    Drug action

    heart rate and cardiac output. … In juxtaglomerular apparatus, nadolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction.

    Drugs: ATP · Nadolol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  4. Pathway

    Oxprenolol Action Pathway

    smpdb.ca/view/SMP0000304
    Drug action

    , heart rate and cardiac output. … In juxtaglomerular apparatus, oxprenolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction.

    Drugs: ATP · Potassium cation · Calcium · Oxprenolol
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  5. Pathway

    Propranolol Action Pathway

    smpdb.ca/view/SMP0000307
    Drug action

    Propranolol binding reduces resting heart rate, cardiac output, blood pressure and orthostatic hypotension. Propranolol also reduce sympathetic activity to manage hyperthyroidism, anxiety and tremor. … Propranolol also competes for beta(2)-adrenergic receptors on bronchial and vascular smooth muscles.

    Drugs: ATP · Propranolol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  6. Pathway

    Quinidine Action Pathway

    smpdb.ca/view/SMP0000323
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … potassium channel (I-Kto), and L-type calcium channels (I-CaL).

    Drugs: ATP · Quinidine · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  7. Pathway

    Disopyramide Action Pathway

    smpdb.ca/view/SMP0000325
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … At rest, the cardiac cell membrane is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier potassium channels (I-K1), which allow an outward flow of potassium

    Drugs: ATP · Disopyramide · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  8. Pathway

    Nebivolol Action Pathway

    smpdb.ca/view/SMP0000366
    Drug action

    Nebivolol (also known as Bystolic or Nebivololum) is a β1-receptor blocker (selective β1-receptor antagonist) that can bind and inhibit Beta-1 adrenergic receptor in muscule and heart. … Nebivolol competes with epinephrine or other beta-1 adrenergic receptor activator to bind on the receptor, which can reduce the heart rate and blood pressure that could caused by biniding of epinephrine

    Drugs: ATP · Potassium cation · Calcium · Nebivolol
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  9. Pathway

    Verapamil Action Pathway

    smpdb.ca/view/SMP0000375
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … At rest, the cardiac cell membrane is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier potassium channels (I-K1), which allow an outward flow of potassium

    Drugs: ATP · Verapamil · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  10. Pathway

    Nifedipine Action Pathway

    smpdb.ca/view/SMP0000379
    Drug action

    Without calcium ions in muscle cell, calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating MLCK. … Nifedipine (also known as Adalat or Procardia) is a dihydropyridine calcium channel blocker that may be used for treatment of hypertension and exertion-related angina in the absence of vasospasm.

    Drugs: ATP · Nifedipine · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4