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Displaying results 151 - 160 of 12626 in total
  1. Target

    Copper-transporting ATPase 2

    go.drugbank.com/bio_entities/BE0003664
    TransporterHumans

    Copper ion transmembrane transporter involved in the export of copper out of the cells. … It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload

    Polypeptides: Copper-transporting ATPase 2Synonyms: Copper pump 2
  2. Target

    CMV DNA Terminase Complex

    go.drugbank.com/bio_entities/BE0010221
    TargetHuman Cytomegalovirus

    Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. … Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex.

  3. Drug

    Dimetacrine

    go.drugbank.com/drugs/DB08996
    ApprovedWithdrawn

    Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe for the treatment of depression. Dimetacrine is no longer used in Japan.

    Categories: Heterocyclic Compounds, 3-RingSynonyms: 3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine
  4. Drug

    Pixofisiran

    go.drugbank.com/drugs/DB17294
    Experimental

    Synonyms: Rna, (a-g-a-a-g-u-u-g-g-c-a-u-g-g-u-a-g-c-c-c-u-u-g-g-g), complex with rna (c-c-c-a-a-g-g-g-c-u-a-c-c-a-u-g-c-c-a-a-c-u-u-c-u) (1:1), Cotsiranib tgf-.beta.1 si-rna free acid component
  5. Indication

    Primary Immune Complex Mediated Membranoproliferative Glomerulonephritis

    go.drugbank.com/conditions/DBCOND0173486
    Drugs: Pegcetacoplan
    Synonyms: Primary Immune Complex Mediated Membranoproliferative Glomerulonephritis
  6. Target

    Diamine oxidase [copper-containing]

    go.drugbank.com/bio_entities/BE0004667
    EnzymePig

    Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:1457410, PubMed:8144586). Its preferred substrates in vitro are the diamines hi...

    Polypeptides: Diamine oxidase [copper-containing]Synonyms: Amine oxidase copper domain-containing protein 1, Amiloride-sensitive amine oxidase [copper-containing]
  7. Drug

    Dienogest

    go.drugbank.com/drugs/DB09123
    ApprovedInvestigational

    It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not available in the US by itself. … In Europe, Australia, Malaysia, Singapore and Japan, dienogest single therapy is an approved treatment for endometriosis to alleviate painful symptoms of endometriosis and reduce endometriotic lesions

    Mixtures: Foxinette 0,03 mg/2 mg 21+7 - Filmtabletten, Velbienne 1 mg/2 mg FilmtablettenCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  8. Drug

    Sumatriptan

    go.drugbank.com/drugs/DB00669
    ApprovedInvestigational

    [L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. … Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.

    Mixtures: TRASS® TABLETA RECUBIERTA, TRASS® TABLETA RECUBIERTACategories: P-glycoprotein substrates, Heterocyclic Compounds, 2-Ring
  9. Target

    Diamine oxidase [copper-containing]

    go.drugbank.com/bio_entities/BE0000351
    TargetEnzymeHumans

    Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:12072962, PubMed:19764817, PubMed:239684, PubMed:8144586). Its preferred substr...

    Polypeptides: Diamine oxidase [copper-containing]Synonyms: Amine oxidase copper domain-containing protein 1
  10. Target

    Copper transport protein ATOX1

    go.drugbank.com/bio_entities/BE0002833
    TargetCarrierHumans

    Multifunctional copper-sensing protein that operates both as a cytosolic copper chaperone and as a copper-dependent transcription factor. … In the cytosol, transfers copper to the copper-transporting ATPase ATP7A at the trans-Golgi network, which is required for activation of secretory copper enzymes including lysyl oxidase (LOX) and SOD3.

    Polypeptides: Copper transport protein ATOX1