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Diphenhydramine
go.drugbank.com/drugs/DB01075ApprovedInvestigationalDiphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies,
Mixtures: ZoDen PD, Live Better Anti-ItchProducts: Best Choice Itch Stopping, Best Choice Childrens Allergy Relief Bubblegum flavorIntegrin alpha-V
go.drugbank.com/bio_entities/BE0003576TargetHumansITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). … ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778).
Synonyms: Vitronectin receptor, Vitronectin receptor subunit alphaInositol 1,4,5-trisphosphate-gated calcium channel ITPR2
go.drugbank.com/bio_entities/BE0009594TargetHumansInositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is ...
Synonyms: IP3 receptor isoform 2, Type 2 InsP3 receptorT-cell surface antigen CD2
go.drugbank.com/bio_entities/BE0000719TargetHumansCD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the si...
Synonyms: LFA-3 receptor, Rosette receptorInositol 1,4,5-trisphosphate-gated calcium channel ITPR3
go.drugbank.com/bio_entities/BE0009595TargetHumansInositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore parti...
Synonyms: IP3 receptor isoform 3, Type 3 InsP3 receptorMidomafetamine
go.drugbank.com/drugs/DB01454IllicitInvestigationalAn N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy. It is a widely abused drug...
Categories: Serotonin Receptor Agonists, Serotonin 5-HT2 Receptor AgonistsVildagliptin
go.drugbank.com/drugs/DB04876ApprovedInvestigationalVildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are i...
Didesmethylrocaglamide
go.drugbank.com/drugs/DB15496ExperimentalDidesmethylrocaglamide is a naturally-occurring derivative of rocaglamide and belongs to a class of anti-cancer phytochemicals referred to as "rocaglamides" derived from plants of the genus Aglaia. While traditionally used for their inse...
Nischarin
go.drugbank.com/bio_entities/BE0003580TargetHumansActs either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling.
Synonyms: Imidazoline receptor 1, Imidazoline-1 receptorCM4620
go.drugbank.com/drugs/DB16466InvestigationalCM4620 (Zegocractin), is under investigation in multiple clinical trials, including NCT04195347 (pancreatitis due to asparaginase), NCT03709342 (PK/PD study in acute pancreatitis), NCT03401190 and NCT04681066 (pancreatitis and SIRS), and...