Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

BE0009595ProteinHumansITPR3

Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584,... It is acted on by 2 drugs in DrugBank.

Gene name
ITPR3
UniProtKB entry
Q14573Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
2,671 residues · 304,104 Da
Also known as
InsP3R3 · IP3 receptor isoform 3 · IP3R-3 · Type 3 inositol 1,4,5-trisphosphate receptor · Type 3 InsP3 receptor

Resolves to

Protein
UniProtQ14573UniProt nameITPR3_HUMAN
Gene
HGNCHGNC:6182NCBI Gene3710GeneCardsITPR3
Pharmacology
KEGGhsa:3710
Structure
PDB6DQJPDB6DQNPDB6DQS
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3, how selective are they, and which programs against it are still in active trials?

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