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NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
go.drugbank.com/bio_entities/BE0000596TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-B22Proteasome subunit alpha type-5
go.drugbank.com/bio_entities/BE0003914TargetHumansComponent of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Synonyms: Multicatalytic endopeptidase complex zeta chainAlprazolam
go.drugbank.com/drugs/DB00404ApprovedIllicitInvestigationalAlprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders. It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole. Benzodiazepine trea...
Proteasome subunit alpha
go.drugbank.com/bio_entities/BE0003353TargetMycobacterium tuberculosisOne function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic … Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
Synonyms: Proteasome core protein PrcAProteasome subunit beta
go.drugbank.com/bio_entities/BE0004188TargetMycobacterium tuberculosisOne function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic … Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
Synonyms: Proteasome core protein PrcBPalovarotene
go.drugbank.com/drugs/DB05467ApprovedFibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder.
Phospholipid-transporting ATPase IF
go.drugbank.com/bio_entities/BE0021215TargetHumansCatalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from
Synonyms: P4-ATPase flippase complex alpha subunit ATP11BMediator of RNA polymerase II transcription subunit 1
go.drugbank.com/bio_entities/BE0004382TargetHumansComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. … Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general
Synonyms: Mediator complex subunit 1, Vitamin D receptor-interacting protein complex component DRIP205Syndecan-2
go.drugbank.com/bio_entities/BE0002116TargetHumansCell surface proteoglycan which regulates dendritic arbor morphogenesis
Synonyms: Heparan sulfate proteoglycan core proteinATX-101
go.drugbank.com/drugs/DB05780InvestigationalDeoxycholic acid is a naturally occurring bile acid produced by the liver as one of several end products of cholesterol metabolism.