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Displaying results 1641 - 1650 of 10000 in total

Target
Proteasome subunit beta type-9
go.drugbank.com/bio_entities/BE0004737
TargetHumans
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic
Synonyms: Multicatalytic endopeptidase complex chain 7
Drug
Lubiprostone
go.drugbank.com/drugs/DB01046
ApprovedInvestigational
A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. … Lubiprostone is a medication used in the management of idiopathic chronic constipation.
Categories: Prostaglandins E
Drug
Arbutamine
go.drugbank.com/drugs/DB01102
Approved
Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in … diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .
Categories: Compounds used in a research, industrial, or household setting
Drug
Human C1-esterase inhibitor
go.drugbank.com/drugs/DB06404
ApprovedInvestigational
[L16586, L16606] This drug is indicated for prophylaxis and treatment of Hereditary Angioedema (HAE), a human genetic disorder caused by a shortage of C1 inhibitor activity that results in an overreaction … The disease is characterized by acute attacks of painful, and in some cases, fatal swelling of several soft tissues or edema, which may last up to five days when untreated.[L16586, L16606]
Categories: Drugs Used in Hereditary Angioedema
Drug
Mipomersen
go.drugbank.com/drugs/DB05528
Approved
Specifically, elevations in the liver enzymes, i.e. transaminases, and in liver fat (hepatic steatosis) have been reported. … Mipomersen is indicated in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering medications.
Categories: Compounds used in a research, industrial, or household setting
Drug
Chlorobutanol
go.drugbank.com/drugs/DB11386
ApprovedVet approvedWithdrawn
Chlorobutanol, or chlorbutol, is an alcohol-based preservative with no surfactant activity [A32746]. … Similar in nature to chloral hydrate, it is formed by the simple nucleophilic addition of chloroform and acetone.
Categories: Compounds used in a research, industrial, or household setting
Drug
Chlorpropamide
go.drugbank.com/drugs/DB00672
ApprovedWithdrawn
Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. … Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites.
Categories: Drugs Used in DiabetesSynonyms: N-(4-chlorophenylsulfonyl)-N'-propylurea, N-(p-chlorobenzenesulfonyl)-N'-propylurea
Drug
Pyridoxal phosphate
go.drugbank.com/drugs/DB00114
ApprovedInvestigationalNutraceutical
This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is tra...
Mixtures: EnlCategories: Vitamin B Complex
Drug
Isoprenaline
go.drugbank.com/drugs/DB01064
ApprovedInvestigational
[L33204] Isoprenaline was granted FDA approval on 19 February 1948.[L33155] … Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion
Synonyms: N-Isopropylnoradrenaline, N-IsopropylnorepinephrineCategories: Compounds used in a research, industrial, or household setting
Drug
Alclofenac
go.drugbank.com/drugs/DB13167
ApprovedWithdrawn
It was withdrawn from the market in the United Kingdom in 1979.