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Displaying results 1661 - 1670 of 1803 in total
  1. Target

    Proteasome subunit alpha type-5

    go.drugbank.com/bio_entities/BE0003914
    TargetHumans

    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

    Synonyms: Multicatalytic endopeptidase complex zeta chain
  2. Target

    Proteasome subunit alpha

    go.drugbank.com/bio_entities/BE0003353
    TargetMycobacterium tuberculosis

    One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic … Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.

    Synonyms: Proteasome core protein PrcA
  3. Target

    Proteasome subunit beta

    go.drugbank.com/bio_entities/BE0004188
    TargetMycobacterium tuberculosis

    One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic … Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.

    Synonyms: Proteasome core protein PrcB
  4. Drug

    Palovarotene

    go.drugbank.com/drugs/DB05467
    Approved

    Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder.

  5. Target

    Phospholipid-transporting ATPase IF

    go.drugbank.com/bio_entities/BE0021215
    TargetHumans

    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from

    Synonyms: P4-ATPase flippase complex alpha subunit ATP11B
  6. Target

    Mediator of RNA polymerase II transcription subunit 1

    go.drugbank.com/bio_entities/BE0004382
    TargetHumans

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. … Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general

    Synonyms: Mediator complex subunit 1, Vitamin D receptor-interacting protein complex component DRIP205
  7. Drug

    ATX-101

    go.drugbank.com/drugs/DB05780
    Investigational

    Deoxycholic acid is a naturally occurring bile acid produced by the liver as one of several end products of cholesterol metabolism.

  8. Target

    Syndecan-2

    go.drugbank.com/bio_entities/BE0002116
    TargetHumans

    Cell surface proteoglycan which regulates dendritic arbor morphogenesis

    Synonyms: Heparan sulfate proteoglycan core protein
  9. Drug

    Segesterone acetate

    go.drugbank.com/drugs/DB14583
    Approved

    In animal studies, segesterone acetate was shown to be one of the most potent progestins [A37090]. It mediates progestational activity 100 times higher than that of [progesterone] [A37092].

  10. Drug

    Ifenprodil

    go.drugbank.com/drugs/DB08954
    ApprovedInvestigationalWithdrawn

    [A220118, A220128] One such allosteric regulator is ifenprodil, which was first shown to bind the NMDARs in the 1990s, and specifically to those NMDARs containing the GluN2B subunit.