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Glucarpidase
go.drugbank.com/drugs/DB08898ApprovedInvestigationalIn 1983, the gene for carboxypeptidase G2, or glucarpidase, was derived from _Pseudomonas_ sp. strain RS-16 to be cloned into _Escherichia coli_, allowing the enzyme to be produced in sufficient quantities … for therapeutic purposes.
Categories: Detoxifying Agents for Antineoplastic TreatmentLonafarnib
go.drugbank.com/drugs/DB06448ApprovedInvestigational[A224379, A224384, A224389, A224394, A224399] Mechanistically, HGPS is underpinned by a single heterozygous C-to-T mutation at position 1824 of the _LMNA_ gene, which results in the accumulation of an … aberrant farnesylated form of lamin A called progerin in the inner nuclear membrane.
Haemangioma
go.drugbank.com/conditions/DBCOND0017266Synonyms: Hemangioma, no International Classification of Diseases for Oncology subtypeMyeloproliferative Disorders
go.drugbank.com/conditions/DBCOND0029888Drugs: ImatinibSynonyms: Chronic myeloproliferative disease, no International Classification of Diseases for Oncology subtypeHydromorphone
go.drugbank.com/drugs/DB00327ApprovedIllicitInvestigational[A176495] The first reported approved product containing hydromorphone in the form of hydromorphone hydrochloride was developed by Fresenius Kabi USA and FDA approved in 1984.[L5795] … Due to these modifications, it presents a very high potency and comparable side effect profile to the parent compound.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Heterocyclic Compounds with 4 or More RingsPolyethylene glycol 400
go.drugbank.com/drugs/DB11077ApprovedInvestigationalPEGylation occurs when PEGs are attached to numerous protein medications, allowing for greater solubility for selected drugs. … It is very hydrophilic, which renders it a useful ingredient in drug formulations to augment the solubility and bioavailability of weakly water-soluble drugs.
Mixtures: Visine for Red Eye Cool, Visine for Red Eye WorkplaceCategories: Compounds used in a research, industrial, or household settingLeucine
go.drugbank.com/drugs/DB00149ApprovedInvestigationalNutraceuticalAn essential branched-chain amino acid important for hemoglobin formation.
Mixtures: GLAMIN SOLUTION FOR INFUSION, KABIVEN EMULSION FOR INFUSIONLuliconazole
go.drugbank.com/drugs/DB08933ApprovedInvestigationalLuliconazole is a topical antifungal agent that acts by unknown mechanisms but is postulated to involve altering the synthesis of fungi cell membranes. … It was approved by the FDA (USA) in November 2013 and is marketed under the brand name Luzu. Luliconazole is also approved in Japan.
Categories: Antifungals for Topical Use, Antifungals for Dermatological UseSulfadimethoxine
go.drugbank.com/drugs/DB06150ApprovedVet approvedWithdrawnIn the US, sulfadimethoxine is one of the products that have been withdrawn or removed from the market after being found to be unsafe or not effective.[L43942] … Sulfadimethoxine is approved in Russia for use in humans, including children, and has been successfully used there for more than 35 years.
Mixtures: Hampiseptol Solution For Injection, TP-SULTRIME 80/400MG/G POWDERCategories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseRanolazine
go.drugbank.com/drugs/DB00243ApprovedInvestigational[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440] … [A189234] Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms.