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Tiotropium
go.drugbank.com/drugs/DB01409ApprovedInvestigational[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation. … [A180163] Tiotropium was granted FDA approval on 30 January 2004.[L7084]
Metyrapone
go.drugbank.com/drugs/DB01011ApprovedInvestigationalAn inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
Rosin
go.drugbank.com/drugs/DB11165ApprovedIn the pharmaceuticals, rosin is used in film forming and coating tablets and enterically administered agents, as well as forming microcapsules and nanoparticles. … Rosin has shown to mediate antibacterial actions on Gram-positive bacterial species [A27267].
Categories: Compounds used in a research, industrial, or household settingIpecac
go.drugbank.com/drugs/DB13293ApprovedWithdrawnuse to cause vomiting in poisoning. … [L1113] The FDA does not have currently any approved product containing ipecac, however, ipecac as an ingredient is accepted to be sold over the counter in packages of 1 fluid ounce (30 ml) for the emergency
Oxytocin
go.drugbank.com/drugs/DB00107ApprovedInvestigationalVet approved[A229008] It plays an important role in pair bonding, social cognition and functioning, and even fear conditioning. … [A229108] Oxytocin continues to be an important tool in modern obstetrics to induce labor when indicated and to manage postpartum hemorrhage.
Terlipressin
go.drugbank.com/drugs/DB02638ApprovedInvestigational[A2601, A2602, A2603, A2604, A2605] It was also studied in hepatorenal syndrome (HRS) and variceal bleeding.[A252672] The drug was first approved by the FDA in September 2022.[L43217] … [L43217] As a potent vasopressor, terlipressin has been investigated in various shock states and conditions with diminished vasomotor tone.
Corticorelin ovine triflutate
go.drugbank.com/drugs/DB09067ApprovedIf corticorelin injection results in an increase of plasma ACTH and cortisol, the patient is diagnosed with Cushing's disease. … However, if corticorelin injection does not result in an increase of plasma ACTH and cortisol, the patient is diagnosed with ectopic ACTH syndrome.
Lipoic acid
go.drugbank.com/drugs/DB00166ApprovedInvestigationalNutraceuticalA vitamin-like antioxidant.
Categories: Compounds used in a research, industrial, or household settingNabumetone
go.drugbank.com/drugs/DB00461ApprovedNabumetone was developed by Smithkline Beecham under the trade name Relafen and first received FDA approval in December, 1991.[L6568] … [A179077] While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract.
Mixtures: NuDroxiPAK N-500Obeticholic acid
go.drugbank.com/drugs/DB05990ApprovedInvestigationalPrimary biliary cirrhosis, or PBC, is a progressive and chronic condition that leads to hepatic injury often resulting in end-stage liver failure that requires liver transplantation. … The NDA from Intercept Pharmaceuticals was approved in November 2019 and obeticholic acid is expected to be granted full approval for this indication in 2020.[L12636]