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Displaying results 1751 - 1760 of 10000 in total
  1. Drug

    Ceritinib

    go.drugbank.com/drugs/DB09063
    ApprovedInvestigational

    Following treatment with crizotinib (a first-generation ALK inhibitor), most tumours develop drug resistance due to mutations in key "gatekeeper" residues of the enzyme. … The FDA approved ceritinib in April 2014 due to a surprisingly high response rate (56%) towards crizotinib-resistant tumours and has designated it with orphan drug status.

    Synonyms: N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propane-2-sulfonamideProducts: ZYKADIA 150 MG, ZYKADIA 150 MG KAPSÜL, 150 ADET
  2. Drug

    Pentosan polysulfate

    go.drugbank.com/drugs/DB00686
    ApprovedInvestigational

    Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties.

    Synonyms: -D-GLUCURONO-.BETA.-D-XYLAN, HYDROGEN SULFATE, -D-GLUCURONO-.BETA.-D-XYLAN, HYDROGEN SULPHATEProducts: ELMIRON 100 MG KAPSÜL, 100 ADET, Elmidam 100 mg Sert Kapsül, 100 ADET
  3. Drug

    Benperidol

    go.drugbank.com/drugs/DB12867
    ApprovedWithdrawn

    Benperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

    Products: BENPERIDOL-NEURAX 10 MG, BENPERIDOL-NEURAX 2 MG
  4. Drug

    Acalabrutinib

    go.drugbank.com/drugs/DB11703
    ApprovedInvestigational

    At this time, more than 35 clinical trials across 40 countries with more than 2500 patients are underway or have been completed with regards to further research into better understanding and expanding … unmet medical need based on a surrogate endpoint.

    Products: CALQUENCE 100 MG SERT KAPSÜL, 60 ADET, CALQUENCE 100 MG SERT KAPSÜL, 56 ADET
  5. Drug

    Isradipine

    go.drugbank.com/drugs/DB00270
    Approved

    It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells

    Products: DYNACIRC SRO 5 MG, DYNACIRC2.5 MG COMPRIMIDOS
  6. Drug

    Lomustine

    go.drugbank.com/drugs/DB01206
    ApprovedInvestigational

    An alkylating agent of value against both hematologic malignancies and solid tumors.

    Synonyms: N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosoureaProducts: CEENU 100 MG CAPSULAS, CEENU © 40 MG. CAPSULAS
  7. Drug

    Binimetinib

    go.drugbank.com/drugs/DB11967
    ApprovedInvestigational

    [A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array BioPharma Inc.) in combination for patients … with unresectable or metastatic melanoma with the BRAF V600E or V600K mutations, as detected by an FDA-approved test.

    Products: MEKTOVI® 15 MG TABLETAS RECUBIERTAS, Mektovı 15 mg Film Kaplı Tablet, 84 ADET
  8. Drug

    Econazole

    go.drugbank.com/drugs/DB01127
    Approved

    It is used topically in dermatomycoses also orally and parenterally.

    Mixtures: TRILON-E CREAMProducts: Pevaryl 10 mg/g Creme, Gyno-Pevaryl 10 mg/g Vaginalcreme
  9. Drug

    Fedratinib

    go.drugbank.com/drugs/DB12500
    ApprovedInvestigational

    [A183176,L8090] It is an anilinopyrimidine derivative.[A183188] Fedratinib was granted FDA approval on August 16, 2019.[L8090]

    Products: Inrebic 100 mg capsules, Inrebic 100 mg Sert Kapsül, 120 ADET
  10. Drug

    Levmetamfetamine

    go.drugbank.com/drugs/DB09571
    Approved

    Levomethamphetamine, the L-enantiomer of methamphetamine is a sympathomimetic vasoconstrictor used in some over-the-counter (OTC) nasal decongestant inhalers in the United States.

    Products: Vapor Inhaler levmetamfetamine nasal decongestant, DG health