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Fosinopril
go.drugbank.com/drugs/DB00492ApprovedInvestigationalIt is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). … Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals
Categories: Antihypertensive Agents Indicated for HypertensionLomefloxacin
go.drugbank.com/drugs/DB00978ApprovedAdditionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. … Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs).
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseTenofovir alafenamide
go.drugbank.com/drugs/DB09299ApprovedInvestigational[T239] Tenofovir alafenamide is an alanine ester form characterized for presenting low systemic levels but high intracellular concentration. … [A178060] Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseGonadorelin
go.drugbank.com/drugs/DB00644ApprovedInvestigationalVet approvedGnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pituitary. … Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis.
Mixtures: Relisorm 500 for Inj.-pws Liq-kit IV Sc, Relisorm 100 for Inj.-pws Liq-kit Sc IVCategories: Tests for Fertility DisturbancesZotepine
go.drugbank.com/drugs/DB09225ApprovedWithdrawnIn the EMA, by 2015 it was under pharmacovigilance studies for the potential treatment of acute renal failure.[L1314] … [L1082] When the analysis of antipsychotics was retaken in 2016 by the FDA, zotepine did not reach the threshold effect to be further studied.[L1313].
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSufentanil
go.drugbank.com/drugs/DB00708ApprovedInvestigationalAlso known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to warrant the use of an opioid analgesic in certified medically supervised healthcare settings … This route of administration is intended to be a simple, effective, non-invasive analgesic option to enable healthcare professionals to rapidly manage acute pain without difficult intravenous or epidural
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromePlasminogen
go.drugbank.com/drugs/DB16701ApprovedInvestigational[L34615] It is the first and only FDA-approved treatment for this condition, which causes wood-like lesions to form on the mucous membranes of patients, providing an unmet medical need for patients with … [A236035] This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond the site of injury.
Piperonyl butoxide
go.drugbank.com/drugs/DB09350ApprovedVet approvedIt has no pesticidal activity of its own, but acts to increase the activity of pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone. … It is used for the treatment of head, pubic (crab), and body lice. Piperonyl butoxide is a synergist.
Mixtures: Para Special Shampoo for Lice & NitsCategories: Compounds used in a research, industrial, or household settingNafcillin
go.drugbank.com/drugs/DB00607ApprovedInvestigationalIt is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. … A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseBalsalazide
go.drugbank.com/drugs/DB01014ApprovedIt is usually administered as the disodium salt. Balsalazide works by deliverying mesalazine to the large intestine to act directly on ulcerative colitis. … Mesalazine is also known as 5-aminosalicylic acid, or 5-ASA.