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Thenalidine

Withdrawn from the Canadian, US, and UK markets in 1963 due to concerns involving neutropenia.

Estetrol

[L33184] Estetrol (E4) is a native estrogen occurring naturally during pregnancy, but can be synthesized from a plant source and used for contraception. … [L33179] In Canada, Nextstellis was approved for use in March 2021; it was developed by Mithra and is marketed by Searchlight Pharma.[L33209]

Glucarpidase

It is a 390-amino acid homodimer protein. … [L39865] It is marketed as VORAXAZE.

Remestemcel-L

Remestemcel-L is a third-party, off-the-shelf suspension of ex-vivo cultured adult human mesenchymal stem cells intended for intravenous infusion. … of the recipients [A31818]. aGvHD is often characterized by the presence of inflammatory cascades through signalling of activated T cells.

Pentagastrin

It works by stimulating the secretion of gastric acid, pepsin, and intrinsic factor. It has also been used as a diagnostic aid.

Theobromine

It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9) … It has a weaker diuretic activity than theophylline and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system.

Ferrous bisglycinate

It is found in foods for food enrichment or in supplements for the treatment of iron deficiency or iron deficiency anemia.

Elexacaftor

[A187361] It received FDA approval in October 2019 in combination with [tezacaftor] and [ivacaftor] as the combination product Trikafta^TM. … [L9395] Elexacaftor is considered a next-generation CFTR corrector as it possesses both a different structure and mechanism as compared to first generation correctors like tezacaftor.

Nedaplatin

It is less nephrotoxic than [DB00515] but has proven equally effective. It was approved for use in Japan in 1995.

Hydrocortisone phosphate