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Displaying results 171 - 180 of 134502 in total
  1. Pathway

    Methyclothiazide Diuretic Action Pathway

    smpdb.ca/view/SMP0123143
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. … The apical membrane contains a calcium channel which transports calcium from the lumen into the epithelial cell, a potassium channel which transports K+ out of the epithelial cell and a Na+/Cl- cotransporter

    Drugs: Methyclothiazide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Trichlormethiazide Action Pathway (New)

    smpdb.ca/view/SMP0123150
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … The apical membrane contains a calcium channel that transports calcium from the lumen into the epithelial cell, a potassium channel that transports K+ out of the epithelial cell, and a Na+/Cl- cotransporter

    Drugs: Trichlormethiazide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Metolazone Action Pathway

    smpdb.ca/view/SMP0123151
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. … The apical membrane contains a calcium channel which transports calcium from the lumen into the epithelial cell, a potassium channel which transports K+ out of the epithelial cell and a Na+/Cl- cotransporter

    Drugs: Metolazone · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Atenolol Action Pathway

    smpdb.ca/view/SMP0000298
    Drug action

    Binding of atenolol inhibits the G protein signalling cascade and reduces heart rate, blood pressure, cardiac output and reflex orthostatic hypotension. … Atenolol is a selective beta-1-adrenoceptor antagonist targeting the heart and vascular smooth muscle to inhibit sympathetic activity.

    Drugs: ATP · Atenolol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  5. Pathway

    Bisoprolol Action Pathway

    smpdb.ca/view/SMP0000300
    Drug action

    Blocking of beta1-adrenergic receptors in heart and vascular smooth muscle can lead to reduced heart rate, cardiac output, and decreased blood pressure. … Bisoprolol (also known as Zebeta) is a selective beta blocker that can block beta1-adrenergic receptors and beta2-adrenergic receptors.

    Drugs: ATP · Bisoprolol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  6. Pathway

    Metoprolol Action Pathway

    smpdb.ca/view/SMP0000302
    Drug action

    , heart rate and cardiac output. … Metoprolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to decreased blood pressure

    Drugs: ATP · Metoprolol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  7. Pathway

    Pindolol Action Pathway

    smpdb.ca/view/SMP0000306
    Drug action

    Without renin, angiotensin II and aldosterone could not be produced, which ultimately prevent water retention and vasoconstriction. … Blocking beta-1 adrenergic receptor could prevent the binding of epinephrine and norepinephrine, which could efficiently reduce blood pressure and heart rate.

    Drugs: ATP · Pindolol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  8. Pathway

    Procainamide (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000324
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … At rest, the cardiac cell membrane is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier potassium channels (I-K1), which allow an outward flow of potassium

    Drugs: ATP · Procainamide · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  9. Pathway

    Fosphenytoin (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000326
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … At rest, the cardiac cell membrane is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier potassium channels (I-K1), which allow an outward flow of potassium

    Drugs: ATP · Phenytoin · Fosphenytoin · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  10. Pathway

    Tocainide Action Pathway

    smpdb.ca/view/SMP0000330
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … At rest, the cardiac cell membrane is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier potassium channels (I-K1), which allow an outward flow of potassium

    Drugs: ATP · Tocainide · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4