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Voxilaprevir Action Pathway
smpdb.ca/view/SMP0125962Drug actionVoxilaprevir is a nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis. The lipoviroparticles attach to LDL...
Fostemsavir Action Pathway
smpdb.ca/view/SMP0125963Drug actionFostemsavir is the phosphonooxymethyl prodrug of temsavir, which is a HIV-1 attachment inhibitor that binds to the gp120 subunit within the HIV-1 gp160 envelope glycoprotein. Fostemavir is the first attachment inhibitor to receive FDA ap...
Amlodipine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126283Drug actionAmlodipine is a calcium channel blocker used to treat hypertension and angina. It can be found under the brand names Amlobenz, Azor, Caduet, Dafiro, Exforge, Exforge Hct, Katerzia, Lotrel, Norliqva, Norvasc, Prestalia, Tribenzor, Twynsta...
Felodipine Action Pathway (New)
smpdb.ca/view/SMP0126294Drug actionFelodipine is a calcium channel blocker used to treat hypertension. It can be found under the brand name Plendil. Felodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calci...
Clevidipine Action Pathway
smpdb.ca/view/SMP0126310Drug actionClevidipine is a dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable. Clevidipine is used IV only and practitioners titrate this drug to lower bl...
Levamlodipine Action Pathway
smpdb.ca/view/SMP0126329Drug actionLevamlodipine is a calcium channel blocker used to treat hypertension. It can be found under the brand name Conjupri. Levamlodipine inhibits L-type calcium channels in vascular smooth muscle, reducing peripheral vascular resistance and b...
Nicardipine Action Pathway
smpdb.ca/view/SMP0126333Drug actionNicardipine is a calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. It can be found under the brand name Cardene. A potent calcium channel blockader with marked vasodilator action. It has...
Pinaverium Action Pathway
smpdb.ca/view/SMP0126336Drug actionPinaverium is a spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract. It can be found under the brand name Dicetel. Pinaverium is a spasmolytic agent used fo...
Verapamil Calcium Channel Vasodilation Action Pathway
smpdb.ca/view/SMP0126373Drug actionVerapamil, known as the brand names Calan, Isoptin, Tarka, and Verelan, is a non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. It is used for the treament of vasopastic angina, uns...
Sphingolipid Signaling (Receptor)
smpdb.ca/view/SMP0524344SignalingSphingosine‑1‑phosphate (S1P) is a potent bioactive lipid mediator synthesized intracellularly by the phosphorylation of sphingosine by sphingosine kinases SphK1 and SphK2 at the plasma membrane and is then exported via spinster 2 (SPNS2...