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Displaying results 171 - 178 of 178 in total
  1. Target

    Inhibin beta B chain

    go.drugbank.com/bio_entities/BE0012584
    TargetHumans

    involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin

  2. Target

    Tyrosine-protein phosphatase non-receptor type 2

    go.drugbank.com/bio_entities/BE0012706
    TargetHumans

    For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the

  3. Target

    Ceramide synthase 1

    go.drugbank.com/bio_entities/BE0012836
    EnzymeHumans

    Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity.

  4. Target

    Volume-regulated anion channel subunit LRRC8A

    go.drugbank.com/bio_entities/BE0016599
    TargetHumans

    Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (By similarity). … cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin

  5. Target

    Relaxin receptor 2

    go.drugbank.com/bio_entities/BE0017729
    TargetHumans

    May also be a receptor for Leydig insulin-like peptide (INSL3)

  6. Target

    NADPH oxidase 4

    go.drugbank.com/bio_entities/BE0019855
    TargetEnzymeHumans

    May regulate insulin signaling cascade (PubMed:14966267). May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (PubMed:15356101, PubMed:15572675).

  7. Target

    Fibroblast growth factor 21

    go.drugbank.com/bio_entities/BE0020031
    TargetHumans

    Regulates systemic glucose homeostasis and insulin sensitivity

  8. Target

    Carcinoembryonic antigens

    go.drugbank.com/bio_entities/BE0010243
    Target

    Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). … Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis.