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Netarsudil
go.drugbank.com/drugs/DB13931ApprovedInvestigationalaqueous As of December 18, 2017 the FDA approved Aerie Pharmaceutical's Rhopressa (netarsudil ophthalmic solution) 0.02% for the indication of reducing elevated intraocular pressure in patients with open-angle
Etuvetidigene Autotemcel
go.drugbank.com/drugs/DB17593ApprovedInvestigationalEtuvetidigene autotemcel is an autologous gene therapy which includes hematopoietic stem cells (HSCs) that have been genetically modified ex vivo. … [L54693] WAS is a rare X-linked disorder caused by a mutation in the gene encoding the WAS protein, leading to a compromised immune system.
Categories: Autologous Hematopoietic Stem Cell-Based Gene TherapyZopapogene imadenovec
go.drugbank.com/drugs/DB24672ApprovedInvestigationalRecurrent respiratory papillomatosis (RRP) is a rare, debilitating disease driven by chronic human papillomavirus (HPV) 6 or 11 infection and characterized by recurrent benign tumors in the respiratory tract. Zopapogene imadenovec is a n...
Synonyms: recombinant replication-deficient Gorilla gorilla gorilla adenovirus strain GC4 vector PRGN-2012 human cytomegalovirus promoter plus human papillomavirus 6/11 E2, E4, E6, E7 protein 11 epitope-containing geneGaretosmab
go.drugbank.com/drugs/DB16379ApprovedInvestigationalGaretosmab-grts is an activin A inhibitor used to treat fibrodysplasia ossificans progressiva (FOP). … [L63940] Garetosmab-grts was approved by the FDA on August 19, 2026 to reduce the number of new heterotopic ossification lesions and clinician-assessed flare-ups in adults with FOP.
Synonyms: Garetosmab-grtsDimethicone
go.drugbank.com/drugs/DB11074ApprovedInvestigationalDimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food produc...
Products: Hair Green Mugungseang, Fresh Green Tea Seed SerumLymphocyte activation gene 3 protein
go.drugbank.com/bio_entities/BE0010189TargetHumansInhibitory receptor on antigen activated T-cells (PubMed:20421648, PubMed:35761082, PubMed:7805750, PubMed:8647185). Delivers inhibitory signals upon binding to ligands, such as MHC class II, its main ligand present at the surface of ant...
Polypeptides: Lymphocyte activation gene 3 proteinTumor susceptibility gene 101 protein
go.drugbank.com/bio_entities/BE0019070TargetHumansComponent of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the assoc...
Polypeptides: Tumor susceptibility gene 101 proteinInsulin-induced gene 2 protein
go.drugbank.com/bio_entities/BE0021304TargetHumansOxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as ...
Polypeptides: Insulin-induced gene 2 proteinLumacaftor
go.drugbank.com/drugs/DB09280ApprovedInvestigationalMutations in the CFTR gene result in altered production, misfolding, or function of the CFTR protein and consequently abnormal fluid and ion transport across cell membranes. … Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, a transmembrane ion
Insulin-induced gene 1 protein
go.drugbank.com/bio_entities/BE0011639TargetHumansOxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16...
Polypeptides: Insulin-induced gene 1 protein