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Displaying results 1841 - 1850 of 10000 in total

Drug
Tiotropium
go.drugbank.com/drugs/DB01409
ApprovedInvestigational
Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma. … [A180163] Tiotropium was granted FDA approval on 30 January 2004.[L7084]
Mixtures: TROFAS 9/50/100 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL, 120 KAPSÜL, SALTIF 9/50/100 MCG INHALASYON IÇIN TOZ IÇEREN BLISTER, 60 DOZCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-Ring
Drug
Agalsidase beta
go.drugbank.com/drugs/DB00103
ApprovedInvestigational
[A220228,A220233] Use of agalsidase beta has decreased in Europe, in favor of agalsidase alfa, after a contamination event in 2009. … Agalsidase beta is a recombinant human α-galactosidase A similar to [agalsidase alfa].
Products: REPLAGAL 1 MG/ML IV İNFÜZYONLUK KONSANTRE ÇÖZELTİ, 1 ADET, FABRAZYME 35 MG İNFÜZYONLUK ÇÖZELTİ İÇİN KONSANTRE TOZ, 1 ADET
Drug
Pentazocine
go.drugbank.com/drugs/DB00652
ApprovedVet approved
It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
Categories: P-glycoprotein substratesProducts: Pentazocine-Fresenius 30 mg/ml injection, Talwin - Liq 30mg/ml
Target
Apolipoprotein(a)
go.drugbank.com/bio_entities/BE0001283
TargetHumans
Lp(a) may be a ligand for megalin/Gp 330 … Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1.
Polypeptides: Apolipoprotein(a)Synonyms: Lp(a), Apo(a)
Target
Exotoxin A
go.drugbank.com/bio_entities/BE0001869
TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis (PubMed:18276581, PubMed:2170123). Ha...
Polypeptides: Exotoxin A
Target
Endoglucanase A
go.drugbank.com/bio_entities/BE0002017
TargetClostridium thermocellum
This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
Polypeptides: Endoglucanase ASynonyms: Cellulase A
Target
Pepsin A
go.drugbank.com/bio_entities/BE0004062
TargetSIV-mac
Polypeptides: Pepsin A
Drug
Ambrisentan
go.drugbank.com/drugs/DB06403
ApprovedInvestigational
It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. … Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy- 3,3-diphenylpropanoic acid
Drug
Inclisiran
go.drugbank.com/drugs/DB14901
ApprovedInvestigational
is a major known risk factor for CVD. … Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density
Categories: Compounds used in a research, industrial, or household setting, Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) InhibitorsProducts: LYPTİMZİA 284 MG/1,5 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADET, LEQVIO SOLUTION FOR INJECTION IN PREFILLED SYRINGE 284 MG/1.5 ML
Drug
Phenylbutazone
go.drugbank.com/drugs/DB00812
ApprovedVet approvedWithdrawn
A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. … It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication).
Categories: Non COX-2 selective NSAIDS, Cytochrome P-450 SubstratesSynonyms: 3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine, 4-n-Butyl-1,2-diphenyl-3,5-pyrazolidinedione