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Displaying results 1861 - 1870 of 3181 in total

Drug
Alosetron
go.drugbank.com/drugs/DB00969
ApprovedWithdrawn
Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gas...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors
Drug
Ezetimibe
go.drugbank.com/drugs/DB00973
ApprovedInvestigational
Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. The discovery and research of this drug began in the early 1990s, after the intravenous administration of radiolabelled ezetimibe in ...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP2C8 Inhibitors
Drug
Telithromycin
go.drugbank.com/drugs/DB00976
Approved
Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors
Drug
Lomefloxacin
go.drugbank.com/drugs/DB00978
Approved
Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors
Drug
Cytarabine
go.drugbank.com/drugs/DB00987
ApprovedInvestigational
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specif...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Doxorubicin
go.drugbank.com/drugs/DB00997
ApprovedInvestigational
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970. Although they both have aglyconic and sugar moieties, doxor...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitors
Drug
Guanfacine
go.drugbank.com/drugs/DB01018
ApprovedInvestigational
Guanfacine, or BS 100-141, is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first descr...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Ketoconazole
go.drugbank.com/drugs/DB01026
ApprovedInvestigational
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increa...
Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
Drug
Memantine
go.drugbank.com/drugs/DB01043
ApprovedInvestigational
Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD).
Categories: N-methyl-D-aspartate Receptor Antagonist, Cytochrome P-450 CYP2A6 InhibitorsProducts: NEMET
Drug
Fluocinonide
go.drugbank.com/drugs/DB01047
ApprovedInvestigational
A topical glucocorticoid used in the treatment of eczema.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers