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Carbaryl Action Pathway
smpdb.ca/view/SMP0126728Drug actionIt acts on insects and due to its relative dosage compared to a human, the lice having their acetylcholinesterase inhibited leading to muscle spasm and eventually death. … Carbaryl is an insecticide in addition to a cholinesterase inhibitor it is used as a treatment to remove head lice.
NGX267 Action Pathway
smpdb.ca/view/SMP0126364Drug actionIt is developed for the treatment of Alzheimer’s disease and has shown the potential to both reduce symptoms and slow disease progression. … The M1 receptor plays an important role in memory and cognitive processing.
Trihexyphenidyl Action Pathway
smpdb.ca/view/SMP0126395Drug actionStructures innervated by the parasympathetic system, such as the salivary glands, eyes, and smooth muscles (directly and indirectly), are affected, even at smaller doses. … Trihexyphenidyl is an antispasmodic drug used as an adjunct drug in the management of parkinsonism and as a treatment for extrapyramidal symptoms caused by drugs affecting the central nervous system (CNS
Pyridostigmine Action Pathway
smpdb.ca/view/SMP0126623Drug actionIt specifically targets and inhibits acetylcholinesterase and cholinesterase, this increases extracellular levels of acetylcholine. … It is usually administered intravenously and is very similar to neostigmine but with a less adverse effect profile and longer duration of action.
Neostigmine Action Pathway (new)
smpdb.ca/view/SMP0126669Drug actionIn the neuron, acetylcholine is synthesized from acetyl-coa and choline, and stored into synaptic vesicles. … Choline is taken back up into the presynaptic neuron and recycled to produce more acetylcholine.
Isoflurophate Action Pathway (new)
smpdb.ca/view/SMP0126686Drug actionIsoflurophate is a cholinesterase inhibitor used to treat glaucoma, as it acts as a powerful miotic agent constricting the pupil and causing the aqueous fluid to flow out and relieve pressure. … It acts by irreversibly binding to acetylcholinesterase and cholinesterase, inhibiting them from breaking down acetylcholine.
Demecarium Action Pathway (new)
smpdb.ca/view/SMP0126687Drug actionprotein receptors and initiating a downstream cascade of effects. … It is a long-acting cholinesterase and very potent, due to this should only be used in patients with open-angle glaucoma.
Rivastigmine Action Pathway (new)
smpdb.ca/view/SMP0126688Drug actionThe drug reversible binds to and inhibits acetylcholinesterase and cholinesterase which stops the breakdown of acetylcholine which increases the concentration in the synaptic cleft. … It is metabolized by the enzymes it inhibits and forms the metabolite NAP226-90.
Ambenonium Action Pathway (new)
smpdb.ca/view/SMP0126691Drug actionAcetylcholine stimulates the nicotinic acetylcholine receptors and causes a cascade resulting in muscle contraction. … Ambenonium allows acetylcholine to be present in the neuromuscular junction for longer and increases the chances of signal transmission.
Malathion Action Pathway
smpdb.ca/view/SMP0126697Drug actionMalathion is an organophosphate which acts to inhibit acetylcholinesterase activity, it acts by binding to cholinesterase stopping the breakdown of acetylcholine to choline and acetic acid. … It is metabolized into metabolites known as malathion dicarboxylic acid, malathion monocarboxylic acid and malaoxon.