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Displaying results 181 - 190 of 135483 in total
  1. Pathway

    Carvedilol Action Pathway

    smpdb.ca/view/SMP0124522
    Drug action

    It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.

    Drugs: ATP · Carvedilol · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  2. Pathway

    Metoprolol Action Pathway (New)

    smpdb.ca/view/SMP0126213
    Drug action

    It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.

    Drugs: ATP · Metoprolol · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  3. Pathway

    Nadolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126214
    Drug action

    It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.

    Drugs: ATP · Nadolol · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  4. Pathway

    Nebivolol Action Pathway (New)

    smpdb.ca/view/SMP0126215
    Drug action

    cAMP, PKA, SRC and nitric oxide synthase signaling. … It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes.

    Drugs: ATP · Calcium · Nebivolol
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  5. Pathway

    Practolol Action Pathway (New)

    smpdb.ca/view/SMP0126221
    Drug action

    It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.

    Drugs: ATP · Practolol · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  6. Pathway

    Propranolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126225
    Drug action

    It is also an antihypertensive and antianginal agent. In bronchial and vascular smooth muscle, propranolol can compete with epinephrine for beta-2 adrenergic receptors. … cAMP, PKA, SRC and nitric oxide synthase signaling.

    Drugs: ATP · Propranolol · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  7. Pathway

    Celiprolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126652
    Drug action

    By blocking the beta-1 receptors the G signalling cascade is blocked, leading to decreased levels of intracellular calcium and muscle relaxation, therefore altering the heart rate. … Celiprolol is a beta-blocker for the management of hypertension and angina pectoris.

    Drugs: ATP · Calcium · Celiprolol
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  8. Pathway

    Trihexyphenidyl Action Pathway

    smpdb.ca/view/SMP0126395
    Drug action

    Structures innervated by the parasympathetic system, such as the salivary glands, eyes, and smooth muscles (directly and indirectly), are affected, even at smaller doses. … Trihexyphenidyl is an antispasmodic drug used as an adjunct drug in the management of parkinsonism and as a treatment for extrapyramidal symptoms caused by drugs affecting the central nervous system (CNS

    Drugs: Choline · Trihexyphenidyl · Calcium · Magnesium cation · Acetylcholine · Acetic acid
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1
  9. Pathway

    Histamine Neurological Sleep Pathway

    smpdb.ca/view/SMP0127073
    Physiological

    conjunctivitis, and urticaria. … H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic

    Drugs: Pyridoxal phosphate · Histidine · Calcium
    Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1B
  10. Pathway

    Mirtazapine H1 Antihistamine Neurological Sleep Action Pathway

    smpdb.ca/view/SMP0145411
    Drug action

    Mirtazapine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. … conjunctivitis, and urticaria.

    Drugs: Pyridoxal phosphate · Histidine · Mirtazapine · Calcium
    Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1B