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Displaying results 181 - 190 of 134165 in total
  1. Pathway

    Fenofibrate Action Pathway

    smpdb.ca/view/SMP0125276
    Drug action

    This PPARα-RXRα complex regulate gene transcription/translation of proteins and enzymes involved lipolysis, fatty acid transport and biosynthesis, vLDL and HDL synthesis. … VLDL and LDL are considered bad cholesterol. These levels are decreased due to downregulation of APOB which forms part of triglyceride-rich vLDL and LDL.

    Drugs: Biotin · Fenofibrate · Magnesium cation
    Enzymes: Apolipoprotein C-III, Apolipoprotein A-II
  2. Pathway

    Bezafibrate Action Pathway (New)

    smpdb.ca/view/SMP0125291
    Drug action

    This PPARα-RXRα complex regulate gene transcription/translation of proteins and enzymes involved lipolysis, fatty acid transport and biosynthesis, vLDL and HDL synthesis. … VLDL and LDL are considered bad cholesterol. These levels are decreased due to downregulation of APOB which forms part of triglyceride-rich vLDL and LDL.

    Drugs: Biotin · Magnesium cation · Bezafibrate
    Enzymes: Apolipoprotein C-III, Apolipoprotein A-II
  3. Pathway

    Gemfibrozil Action Pathway

    smpdb.ca/view/SMP0125290
    Drug action

    This PPARα-RXRα complex regulate gene transcription/translation of proteins and enzymes involved lipolysis, fatty acid transport and biosynthesis, vLDL and HDL synthesis. … VLDL and LDL are considered bad cholesterol. These levels are decreased due to downregulation of APOB which forms part of triglyceride-rich vLDL and LDL.

    Drugs: Biotin · Gemfibrozil · Magnesium cation
    Enzymes: Apolipoprotein C-III, Apolipoprotein A-II
  4. Pathway

    Mechanisms of Fibrosis

    smpdb.ca/view/SMP0540197
    Signaling

    and the formation of scar tissue. … and myofibroblast differentiation.

    Drugs: Magnesium cation
    Enzymes: Collagen alpha-1(III) chain
  5. Pathway

    Peginterferon alfa-2a Action Pathway

    smpdb.ca/view/SMP0125981
    Drug action

    Peginterferon alfa-2a is a modified form of recombinant human interferon, which is used to activate interferon alpha receptors in the JAK-STAT pathway. … Peginterferon alfa-2a activate interferon alpha receptors 1 and 2 (IFNAR1 and IFNAR2) which are associated with tyrosine kinase 2 (TYK2) and JAK1 respectively.

    Drugs: Peginterferon alfa-2a
    Enzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2
  6. Pathway

    Peginterferon alfa-2b Action Pathway

    smpdb.ca/view/SMP0126026
    Drug action

    Peginterferon alfa-2b, also known as Pegintron or Sylatron, is a purified recombinant human interferon. … Its immunomodulatory effects are the enhancement of the phagocytic activity, the activation of NK cells, the stimulation of cytotoxic T-lymphocytes, and the upregulation of the Th1 T-helper cell subset

    Drugs: Peginterferon alfa-2b
    Enzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2
  7. Pathway

    Interferon beta-1a Action Pathway

    smpdb.ca/view/SMP0126027
    Drug action

    Interferon beta-1a is a recombinant form of the human interferon. It is used to slow disease progression and reduce the clinical symptoms of patients with relapsing multiple sclerosis (RMS). … They act through IKKa and IKKb to drive NFKB induction of genes associated with survival signals, antigen processing and presentation, and proliferation.

    Drugs: Interferon beta-1a
    Enzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2
  8. Pathway

    Triflusal Action Pathway (new)

    smpdb.ca/view/SMP0126547
    Drug action

    Due to the anticoagulant and antiplatelet nature, herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Triflusal is administered orally and acts as an antithrombotic anticoagulant that irreversibly inhibits cyclooxygenase-1(COX-1) also known as prostaglandin g/h synthase 1.

    Drugs: Adenosine phosphate · ATP · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Mesoheme +2 more
    Enzymes: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  9. Pathway

    Cardiolipin Biosynthesis CL(10:0/10:0/14:0/21:0)

    smpdb.ca/view/SMP0175412
    Metabolic

    Sixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Cardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition.

    Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphate
    Enzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
  10. Pathway

    Cardiolipin Biosynthesis CL(10:0/10:0/17:0/19:0)

    smpdb.ca/view/SMP0175481
    Metabolic

    Sixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Cardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition.

    Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphate
    Enzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1