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Displaying results 181 - 190 of 597 in total
  1. Pathway

    Olfactory Transduction OR5AC2

    smpdb.ca/view/SMP0713863
    Physiological

    The rise in intracellular cAMP concentration opens cyclic nucleotide–gated ion channels, allowing sodium (Na⁺) and calcium (Ca²⁺) ions to flow into the neuron. … The OR5AC2 receptor has been implicated in the detection of fruity, floral, and musk-like odorants, with reported responsiveness to compounds such as heliotropin (piperonal) and ionone derivatives, which

    Drugs: ATP · Calcium · Cyclic adenosine monophosphate
    Enzymes: Calcium-activated chloride channel regulator 1
  2. Pathway

    Olfactory Transduction OR2AG1

    smpdb.ca/view/SMP0713866
    Physiological

    The elevated cAMP concentration opens cyclic nucleotide–gated ion channels, allowing sodium (Na⁺) and calcium (Ca²⁺) ions to enter the neuron. The influx of these ions depolarizes the cell membrane. … When odorant molecules enter the nasal cavity and dissolve in the mucus layer, specific odorants bind to the OR2AG1 receptor.

    Drugs: ATP · Calcium · Cyclic adenosine monophosphate
    Enzymes: Calcium-activated chloride channel regulator 1
  3. Pathway

    Olfactory Transduction OR2J3

    smpdb.ca/view/SMP0713867
    Physiological

    The increase in intracellular cAMP opens cyclic nucleotide–gated ion channels, allowing sodium (Na⁺) and calcium (Ca²⁺) ions to enter the neuron. … When volatile odorant molecules enter the nasal cavity and dissolve in the mucus layer, certain ligands selectively bind to the OR2J3 receptor.

    Drugs: ATP · Calcium · Cyclic adenosine monophosphate
    Enzymes: Calcium-activated chloride channel regulator 1
  4. Pathway

    Olfactory Transduction OR5A1

    smpdb.ca/view/SMP0713868
    Physiological

    Elevated cAMP levels open cyclic nucleotide–gated ion channels, permitting the influx of sodium (Na⁺) and calcium (Ca²⁺) ions into the neuron. … Notably, OR2A4 is part of the OR2A subfamily, which includes receptors with overlapping ligand specificity and broad responsiveness to terpenoid and aromatic alcohols.

    Drugs: ATP · Calcium · Cyclic adenosine monophosphate
    Enzymes: Calcium-activated chloride channel regulator 1
  5. Pathway

    Olfactory Transduction OR1E3

    smpdb.ca/view/SMP0713869
    Physiological

    The rise in intracellular cAMP opens cyclic nucleotide–gated ion channels, allowing sodium (Na⁺) and calcium (Ca²⁺) ions to flow into the neuron. … The OR1E3 receptor has been shown to respond to floral and fruity odorants, particularly citronellol and related alcohols with rose-like or citrus notes.

    Drugs: ATP · Calcium · Cyclic adenosine monophosphate · Acetophenone
    Enzymes: Calcium-activated chloride channel regulator 1
  6. Pathway

    Olfactory Transduction OR1C1

    smpdb.ca/view/SMP0713870
    Physiological

    The rise in cAMP concentration opens cyclic nucleotide–gated ion channels, permitting the influx of sodium (Na⁺) and calcium (Ca²⁺) ions. This depolarizes the neuronal membrane. … When odorant molecules enter the nasal cavity and dissolve in the mucus layer, specific ligands bind to the OR1C1 receptor.

    Drugs: ATP · Calcium · Cyclic adenosine monophosphate
    Enzymes: Calcium-activated chloride channel regulator 1
  7. Pathway

    Olfactory Transduction OR1L3

    smpdb.ca/view/SMP0713871
    Physiological

    The increase in intracellular cAMP concentration opens cyclic nucleotide–gated ion channels, allowing sodium (Na⁺) and calcium (Ca²⁺) ions to flow into the neuron. … The OR1L3 receptor has been shown to respond to several floral and aromatic compounds, including helional, cinnamaldehyde, and citronellol.

    Drugs: ATP · Calcium · Cyclic adenosine monophosphate
    Enzymes: Calcium-activated chloride channel regulator 1
  8. Pathway

    Misoprostol Action Pathway

    smpdb.ca/view/SMP0124718
    Drug action

    Misoprostol may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing

    Drugs: ATP · Misoprostol · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate +1 more
    Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1
  9. Pathway

    Amiodarone Action Pathway (New)

    smpdb.ca/view/SMP0122646
    Drug action

    , due to its effects on other targets such as beta-adrenergic receptors, sodium channels, and calcium channels. … Amiodarone targets the cardiac myocytes where it blocks the inward rectifying potassium channels. This potassium is responsible for phase 3 of the action potential.

    Drugs: ATP · Amiodarone · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium/calcium exchanger 1
  10. Pathway

    Dofetilide Action Pathway

    smpdb.ca/view/SMP0126189
    Drug action

    In the presence of dofetilide, K+ accumulates in the cell since the potassium channels are blocked by the drug (rectifier potassium current). … This drug is used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter.

    Drugs: ATP · Dofetilide · Potassium cation · Calcium
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium/calcium exchanger 1