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dTTP/UTP pyrophosphatase
go.drugbank.com/bio_entities/BE0001527TargetBacillus subtilis (strain 168)Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. … Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-CTP (m(5)CTP) and 5-methyl-UTP (m(5)UTP) (PubMed:24210219).
Polypeptides: dTTP/UTP pyrophosphataseSynonyms: Nucleotide pyrophosphatase, Nucleoside triphosphate pyrophosphataseADP-ribose pyrophosphatase
go.drugbank.com/bio_entities/BE0001935TargetHumansHydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate (PubMed:11385575, PubMed:37343711). Has also a weak phosphohydrolase activity against NADH and FAD (in vitro) (PubMed:37343711)
Polypeptides: ADP-ribose pyrophosphataseSynonyms: Adenosine diphosphoribose pyrophosphataseSolute carrier organic anion transporter family member 4A1
go.drugbank.com/bio_entities/BE0003656TransporterHumansRecognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol … Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886).
Synonyms: Sodium-independent organic anion transporter EAlpha-2-macroglobulin
go.drugbank.com/bio_entities/BE0000910TargetCarrierHumansFollowing cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
go.drugbank.com/bio_entities/BE0000931TargetHumansHas ADP-ribosyltransferase activity toward GLP1R
Synonyms: ADP-ribosyltransferase C2 and C3 toxin-like 1SPARC
go.drugbank.com/bio_entities/BE0002145TargetHumansBinds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. … There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity
Synonyms: Secreted protein acidic and rich in cysteineZinc transporter ZIP4
go.drugbank.com/bio_entities/BE0009894TransporterHumansAlso exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589) … Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:17202136, PubMed:32348750).
Synonyms: Zrt- and Irt-like protein 4Zinc transporter ZIP3
go.drugbank.com/bio_entities/BE0009904TransporterHumansTransporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted m...
Synonyms: Zrt- and Irt-like protein 3Zinc transporter ZIP9
go.drugbank.com/bio_entities/BE0009905TransporterHumansThis pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). … Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis (PubMed:19420709, PubMed:25014355, PubMed:28219737).
Synonyms: Zrt- and Irt-like protein 9Adenylate cyclase
go.drugbank.com/bio_entities/BE0010179TargetHumansMay play a role in memory and learning. … Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity).
Synonyms: ATP pyrophosphate-lyase 1, ATP pyrophosphate-lyase 2