Alpha-2-macroglobulin

BE0000910ProteinHumansA2M

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. It is acted on by 15 drugs in DrugBank.

Gene name
A2M
UniProtKB entry
P01023Swiss-Prot
Cellular location
Secreted
Residues / weight
1,474 residues · 163,290 Da
Also known as
Alpha-2-M · C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 · CPAMD5

Resolves to

Protein
UniProtP01023UniProt nameA2MG_HUMAN
Gene
HGNCHGNC:7NCBI Gene2GenBank177870GeneCardsA2M
Pharmacology
KEGGhsa:2
Structure
PDB1BV8PDB2P9RPDB6TAV
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-2-macroglobulin, how selective are they, and which programs against it are still in active trials?

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