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Displaying results 181 - 190 of 104416 in total
  1. Target

    DNA polymerase I

    go.drugbank.com/bio_entities/BE0003871
    TargetGeobacillus stearothermophilus

    In addition to polymerase activity, the recombinant enzyme has strand displacement and 5'-3' exonuclease activity, but lacks proofreading 3'-5' exonuclease activity.

    Polypeptides: DNA polymerase ISynonyms: POL I
  2. Target

    Complement factor I

    go.drugbank.com/bio_entities/BE0009054
    TargetHumans

    Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the al...

    Polypeptides: Complement factor I
  3. Drug

    Hydroquinone

    go.drugbank.com/drugs/DB09526
    ApprovedInvestigational

    It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. … As a result of these concerns, hydroquinone has been banned in the EU and UK.

    Mixtures: Throwers Pbc No. 1, CREMA CON ACIDO GLICOLICO AL 8%Categories: Compounds used in a research, industrial, or household setting
  4. Drug

    Vitamin A

    go.drugbank.com/drugs/DB00162
    ApprovedInvestigationalNutraceuticalVet approved

    Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the … Dietary vitamin A is derived from a variety of carotenoids found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.

    Synonyms: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol, Vitamin A AlcoholInternational brands: Chocola A
  5. Drug

    Levocarnitine

    go.drugbank.com/drugs/DB00583
    ApprovedInvestigational

    It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.

    Mixtures: Q 10 Suprabio +L-Carnitine, Q-GEL CARNI SOFTSULESynonyms: 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt, (R)-Carnitine
  6. Target

    DNA polymerase I, thermostable

    go.drugbank.com/bio_entities/BE0001665
    TargetThermus aquaticus

    In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity (By similarity). Unlikely to have 3'-5' exonuclease activity due to absence of a 3'-5' exonuclease domain (Probable).

    Polypeptides: DNA polymerase I, thermostable
  7. Target

    Type I iodothyronine deiodinase

    go.drugbank.com/bio_entities/BE0009854
    EnzymeTargetHumans

    Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:32718224, PubMed:18821722). Catalyzes the deiodination of L-thyroxine (T4) ...

    Polypeptides: Type I iodothyronine deiodinaseSynonyms: Type-I 5'-deiodinase
  8. Drug

    Medroxyprogesterone acetate

    go.drugbank.com/drugs/DB00603
    ApprovedInvestigational

    [A14848] MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prevent pregnancy, … Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties.

    Mixtures: OBAT SUNTIK KB II, DIVICONT TABLETAS 1 MG/5 MGCategories: Pregnen (4) Derivatives, P-glycoprotein inhibitors
  9. Drug

    Nicotinamide

    go.drugbank.com/drugs/DB02701
    ApprovedInvestigational

    An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. … Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.

    Synonyms: 3-pyridinecarboxamide, β-pyridinecarboxamideMixtures: Lebody Bu W Renewal Up, Ouhi Cell Power No 1 Essence
  10. Drug

    Nitrofurantoin

    go.drugbank.com/drugs/DB00698
    ApprovedInvestigationalVet approved

    [L6856,L6859,L6862] Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. … [A179824] This drug is more resistant to the development of bacterial resistance because it acts on many targets at once.

    Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingSynonyms: N-(5-Nitrofurfurylidene)-1-aminohydantoin, 1-((5-nitro-2-furanyl)methylene)amino-2,4-imidazolidenedione