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Melanoma antigen preferentially expressed in tumors
go.drugbank.com/bio_entities/BE0010493TargetHumansThe CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). … Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980
Polypeptides: Melanoma antigen preferentially expressed in tumorsSynonyms: Preferentially expressed antigen of melanomaPF-04937319
go.drugbank.com/drugs/DB15009InvestigationalPF-04937319 is under investigation in clinical trial NCT01513928 (A Study To Compare The Pharmacokinetics Of Different Formulations Of PF-04937319 In Healthy Subjects).
(+)-Mefloquine
go.drugbank.com/drugs/DB05636Investigationalcompare the efficacy of (+) Mefloquine vs. racemic [Mefloquine]. … (+)-Mefloquine was under investigation in clinical trial NCT00931697 (Study to Investigate the Safety, Tolerability and Pharmacokinetics of AD 452 [(+)-Mefloquine] Compared With Racemic Mefloquine) to
Ventilator Associated Bacterial Pneumonia (VABP) caused by Acinetobacter Baumannii-calcoaceticus Complex
go.drugbank.com/conditions/DBCOND0159091Synonyms: Ventilator Associated Bacterial Pneumonia (VABP) caused by Acinetobacter Baumannii-calcoaceticus ComplexB-cell antigen receptor complex-associated protein beta chain
go.drugbank.com/bio_entities/BE0009680TargetHumansRequired in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to
Polypeptides: B-cell antigen receptor complex-associated protein beta chainVentricular Ectopic Beat
go.drugbank.com/conditions/DBCOND0120769Drugs: HydroquinidineSynonyms: Ventricular premature complex, Premature Ventricular ComplexDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
go.drugbank.com/bio_entities/BE0000065TargetHumansThe pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle … Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA
Polypeptides: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialSynonyms: M2 antigen complex 70 kDa subunit, Pyruvate dehydrogenase complex component E2Triggering receptor expressed on myeloid cells 2
go.drugbank.com/bio_entities/BE0020451TargetHumansForms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849).
Polypeptides: Triggering receptor expressed on myeloid cells 2Synonyms: Triggering receptor expressed on monocytes 2Triggering receptor expressed on myeloid cells 1
go.drugbank.com/bio_entities/BE0001288TargetHumansUpon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:17568691, PubMed:25595774, PubMed:29568119).
Polypeptides: Triggering receptor expressed on myeloid cells 1Synonyms: Triggering receptor expressed on monocytes 1Ociperlimab
go.drugbank.com/drugs/DB18947InvestigationalOciperlimab is under investigation in clinical trial NCT04866017 (A Study to Compare Ociperlimab Plus Tislelizumab Versus Durvalumab Following Concurrent Chemoradiotherapy (Ccrt) in Patients With Stage