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Activated CDC42 kinase 1
go.drugbank.com/bio_entities/BE0000772TargetHumansContributes to the control of AXL receptor levels. … Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin.
Synonyms: Tyrosine kinase non-receptor protein 2Integrin alpha-M
go.drugbank.com/bio_entities/BE0010412TargetHumansIt is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. … Integrin ITGAM/ITGB2 is also a receptor for ICAM1 ligand ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124).
Synonyms: Neutrophil adherence receptor, Leukocyte adhesion receptor MO1High affinity cationic amino acid transporter 1
go.drugbank.com/bio_entities/BE0000212TargetTransporterHumansHigh-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues
Synonyms: Ecotropic retrovirus receptor homolog, Ecotropic retroviral leukemia receptor homologBupropion
go.drugbank.com/drugs/DB01156ApprovedInvestigational[L6562,A179038,A179050] The combination of naltrexone and bupropion was shown to result in a statistically significant weight loss, with a mean change in body weight of -6.3% compared to -1.3% for placebo … [L6562] Studies have shown that the combined activity of bupropion and [naltrexone] increase the firing rate of hypothalamic pro-opiomelanocortin (POMC) neurons and blockade of opioid receptor-mediated
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesHepatocyte nuclear factor 4-gamma
go.drugbank.com/bio_entities/BE0003179TargetHumansTranscription factor. Has a lower transcription activation potential than HNF4-alpha
Synonyms: Nuclear receptor subfamily 2 group A member 2Mediator of RNA polymerase II transcription subunit 1
go.drugbank.com/bio_entities/BE0004382TargetHumansComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the ...
Synonyms: Thyroid receptor-interacting protein 2, Peroxisome proliferator-activated receptor-binding proteinLenacapavir
go.drugbank.com/drugs/DB15673ApprovedInvestigationalHIV/AIDS remains an area of concern despite the introduction of numerous successful therapies, mainly due to the emergence of multidrug resistance and patient difficulty in adhering to treatment regimens. Lenacapavir is a first-in-class ...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesMethadone
go.drugbank.com/drugs/DB00333ApprovedInvestigational[F4685,F4688,F4691] Treatment of opioid addiction with methadone, [buprenorphine], or slow-release oral [morphine] (SROM) is termed Opioid Agonist Treatment (OAT) or Opioid Substitution Therapy (OST … Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist.
Categories: NMDA Receptor Antagonists, P-glycoprotein inhibitorsNeutral amino acid transporter B(0)
go.drugbank.com/bio_entities/BE0000236TargetTransporterHumansMediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons.
Synonyms: Baboon M7 virus receptor, RD114/simian type D retrovirus receptorAcetic acid
go.drugbank.com/drugs/DB03166ApprovedInvestigationalAcetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) Acetic acid otic (for the ear) ...
Mixtures: Fem pH, Acetate Buffer Ph 4.85