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Neutral amino acid transporter B(0)
go.drugbank.com/bio_entities/BE0000236TargetTransporterHumansMediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons.
Synonyms: Baboon M7 virus receptor, RD114/simian type D retrovirus receptorDeoxyhypusine hydroxylase
go.drugbank.com/bio_entities/BE0018877TargetHumansCatalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-tran...
Synonyms: HEAT-like repeat-containing protein 1CD320 antigen
go.drugbank.com/bio_entities/BE0019797TransporterHumansReceptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213).
Synonyms: Transcobalamin receptorVolume-regulated anion channel subunit LRRC8A
go.drugbank.com/bio_entities/BE0016599TargetHumansEssential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubM...
Synonyms: Leucine-rich repeat-containing protein 8AMethadone
go.drugbank.com/drugs/DB00333ApprovedInvestigational[F4685,F4688,F4691] Treatment of opioid addiction with methadone, [buprenorphine], or slow-release oral [morphine] (SROM) is termed Opioid Agonist Treatment (OAT) or Opioid Substitution Therapy (OST … Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist.
Categories: NMDA Receptor Antagonists, P-glycoprotein inhibitorsSteroidogenic factor 1
go.drugbank.com/bio_entities/BE0003359TargetHumansTranscriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B a...
Synonyms: Steroid hormone receptor Ad4BP, Nuclear receptor subfamily 5 group A member 1Bismuth subgallate
go.drugbank.com/drugs/DB13909ApprovedBismuth subgallate is a yellow colored substance that presents as an odorless powder that undergoes discoloration when exposed to sunlight. It is a heavy metal salt of gallic acid that is highly insoluble and poorly absorbed. Possessing ...
Janus (JAK) kinases
go.drugbank.com/bio_entities/BE0027976TargetHumansInvolved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR … Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR
Polypeptides: Non-receptor tyrosine-protein kinase TYK2Function: acetylcholine receptor bindingTransforming growth factor beta activator LRRC32
go.drugbank.com/bio_entities/BE0014554TargetHumansKey regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed:19750484, PubMed:22278742). As...
Synonyms: Leucine-rich repeat-containing protein 32Function: receptor ligand inhibitor activityDupilumab
go.drugbank.com/drugs/DB12159ApprovedInvestigationalDupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. … [A180478] As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that induce inflammatory and immunological reactions in
Categories: Interleukin-4 Receptor alpha Antagonist, Interleukin 4 Receptor alpha Antagonists